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Human Apo Transferrin (plasma, <8ppm Iron) recombinant Protein
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Proteine Synonyms: Serotransferrin, Transferrin, Siderophilin, Beta-1-metal-binding globulin, TF, PRO1557, PRO2086, DKFZp781D0156, Apo Transferrin, ATF. Source: Human Serum Purity: ≥ 98 % (SDS-PAGE, Cellulose Acetate electrophoresis) Iron Content: <8 ppm (estimated by ICP) Buffer: 20mM NH4HCO3 (lyophilized product may contain traces of buffer salts Physical State: Sterile filtered, lyophilized Manufacturer: |
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Active Bioscience
Produktdetails
Synonyms
Serotransferrin, Transferrin, Siderophilin, Beta-1-metal-binding globulin, TF, PRO1557, PRO2086, DKFZp781D0156, Apo Transferrin, ATF.
Description of Human Apo Transferrin (plasma, <8ppm Iron)
Human Apo Transferrin (ATF) is a glycoprotein with a molecular mass of approximately 77 kDa. As the primary iron-transport protein in vertebrate serum, Transferrin plays a crucial role in delivering iron to cells through its interaction with the specific membrane receptor CD71. This protein is essential for most cells cultivated in tissue culture environments. Transferrin is often categorized as a growth factor due to its critical role in cellular proliferation. Rapidly dividing cells express high numbers of transferrin receptors, and the binding of transferrin to these receptors is necessary for cells to initiate and maintain DNA synthesis. Beyond its iron-carrying capacity, transferrin also functions as a cytokine, exhibiting additional roles unrelated to iron transport.
Physcial State
Sterile filtered, lyophilized
Human Virus Test
Plasma from each donor has been tested and found negative for antibodies to HIV-1, HIV-2, HCV, HBSAG, HBc, HBV, HAV and Syphilis.
Reconstitution
We recommend reconstitution in sterile water to a concentration of 1mg/ml, which can then be further diluted to other aqueous solutions. Do not vortex.
Stability
Lyophilized human Apo Transferrin is stable at room temperature for up to 3 weeks, and until expiry date if stored at 2 to 8°C. Do not freeze. Reconstituted human ATF can be stored at 4°C for 2-7 days and in working aliquots below -20°C for future use. Please avoid repeated freeze-thaw cycles.
Applications
- Cell Culture: Human Transferrin is a vital component in the cultivation of mammalian cells in vitro, supporting long-term cell growth
- Media Detoxification: It acts as a detoxificant in culture media by binding contaminating metal ions
- Biopharmaceutical Production: Human Transferrin is frequently used as a nutrient in fermentation media for recombinant protein and biopharmaceutical production
- Antibody Purification: Human Transferrin is used in the affinity purification of anti-human transferrin antibodies
- Receptor-Mediated Transfection: It facilitates the receptor-mediated transfection of molecules, such as DNA, into cells
- Iron Homeostasis Studies: Transferrin is crucial in research focused on iron metabolism and related disorders
- Cancer Research: Given its role in cellular proliferation, transferrin is significant in studies related to cancer cell growth and potential therapeutic targets
- Neurodegenerative Disease Research: Transferrin's iron-binding properties make it relevant in studies of neurodegenerative diseases associated with iron accumulation
- Drug Delivery Systems: The transferrin receptor pathway is being explored for targeted drug delivery, particularly in crossing the blood-brain barrier
Shipped at room temperature
Verwendung: Nur für Forschungszwecke. Nicht zur Verwendung in diagnostischen oder therapeutischen Verfahren. Nicht für den menschlichen Gebrauch.
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