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Human Thrombospondin
Native, whole molecule
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Proteine Synonyms: THBS1, THBS, TSP1, TSP, Thrombospondin-1, Glycoprotein G Source: Human Platelets Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 20 mM Tris-HCl, pH 8.0, with 600 mM NaCl, 2 mM CaCl2, and 20% sucrose. Reconstitution: After centrifugation, we suggest addition of de-ionized H2O to the original volume, followed by gentle mixing to ensure adequate homogenization. This product may precipitate at concentrations greater than 0.50 mg/ml. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
THBS1, THBS, TSP1, TSP, Thrombospondin-1, Glycoprotein G
Description of Human Thrombospondin
Human Thrombospondin is a 420 kDa protein. Thrombospondin is a multifunctional family of secreted glycoproteins, best known for their central role in mediating cell-to-cell and cell-to-matrix interactions within the extracellular matrix. The most studied member, thrombospondin-1 (TSP-1), is a matricellular protein that regulates diverse biological processes, including cell adhesion, migration, proliferation, apoptosis, and angiogenesis. TSP-1 is a key modulator of platelet aggregation and is released from platelet α-granules upon activation, where it interacts with fibrinogen and other receptors to influence coagulation and platelet function. Beyond hemostasis, TSP-1 exerts potent antiangiogenic effects by inhibiting endothelial cell migration and proliferation, and by activating transforming growth factor-beta (TGF-β), thus contributing to tissue remodeling and fibrosis. Dysregulation of thrombospondin expression is implicated in several diseases. Elevated TSP-1 levels are associated with renal disease, where it promotes fibrosis and contributes to the progression of chronic kidney disease. It also plays a role in cardiovascular diseases, obesity, diabetes, and cancer, influencing immune responses, tumor growth, and metastasis. Clinically, thrombospondin is being explored as a biomarker for platelet activation, renal dysfunction, and certain cancers, such as pancreatic and cholangiocarcinoma, with potential diagnostic and prognostic applications. Its diverse functions and disease associations make thrombospondin a promising target for therapeutic intervention and biomarker development.
Source
Prepared from platelets shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Storage
For long term, store Human Thrombospondin at ≤ -20°C.
Applications
Cardiovascular Disease, Kidney Disease, Coagulation, Angiogenisis, Cancer, Infection , Inflammation, In Vitro Diagnostic.
Citations/Publications
Zhang, Y., et al., (2018, ), 'Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers.', NATURE COMMUNICATIONS. 9: pp 4080. Available at: DOI: 10.1038/s41467-018-06177-2
Labrousse-Arias, D., et al., (2016), ' HIF-2a-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction', Cardiovascular Research 109: pp 115–130. Available at: doi:10.1093/cvr/cvv243
Rogers, N. M., et al., (2016), 'CD47 regulates renal tubular epithelial cell self-renewal and proliferation following renal ischemia reperfusion.', Kidney International 90: pp 334–347. Available at: http://dx.doi.org/10.1016/j.kint.2016.03.034
Meijles, D. N., et al., (2017), 'The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1', Sci Signal. 10(501): eaaj1784. Available at: doi:10.1126/scisignal.aaj1784.
Neubauer, E. F., et al., (2017), 'A diverse host thrombospondin-type-1 repeat protein repertoire promotes symbiont colonization during establishment of cnidarian-dinoflagellate symbiosis', eLife 6:e24494. Available at: DOI:10.7554/eLife.24494
NCBI: https://www.ncbi.nlm.nih.gov/protein/P07996/
Shipped with ice packs
Gel Scan of Human Thrombospondin
| Fig. 1: SDS-PAGE Gel |
Verwendung: Nur für Forschungszwecke. Nicht zur Verwendung in diagnostischen oder therapeutischen Verfahren. Nicht für den menschlichen Gebrauch.
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