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Human Transferrin, Saturated, Tissue Culture Grade
Native, whole molecule. Iron Saturated, Tissue Culture Grade
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Proteine Synonyms: Trf, Siderophilin, Serotransferrin, Beta-1 metal-binding globulin, TRF, TF, PRO1400, PRO1557 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. Endotoxin Level: ≤0.1EU/mg by LAL testing. Sterile filtered using 0.2 micron filter. Iron Content: ≥ 1100 µg/g Physical State: Lyophilized from sterile de-ionized water, pH 7.0-7.5. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
Trf, Siderophilin, Serotransferrin, Beta-1 metal-binding globulin, TRF, TF, PRO1400, PRO1557
Description of Human Transferrin, Saturated, Tissue Culture Grade
Human Transferrin, Saturated, Tissue Culture Grade is a 80 kDa protein. Transferrin is a multifunctional monomeric glycoprotein primarily synthesized in the liver and found abundantly in plasma, where it plays a central role in iron metabolism and homeostasis. Each transferrin molecule can reversibly bind two ferric (Fe³⁺) ions with high affinity, facilitating the safe transport and regulated distribution of iron from absorption sites in the gut and macrophages to tissues throughout the body, especially to the bone marrow for hemoglobin synthesis. This iron delivery is mediated through transferrin receptors on cell surfaces, enabling receptor-mediated endocytosis and precise cellular iron uptake. Beyond iron transport, transferrin possesses significant antimicrobial properties by sequestering free iron, thereby limiting its availability to bacteria and fungi-a process that contributes to innate immune defense and exhibits bacteriostatic and fungistatic effects. Clinically, altered transferrin levels are linked to various conditions: increases are seen in iron-deficiency anemia and pregnancy, while decreases occur in inflammatory diseases, nephrotic syndrome, hypoproteinemia, and rare genetic disorders like atransferrinemia, which causes severe anemia and iron overload in tissues. Transferrin’s applications extend to clinical diagnostics, where it serves as a biomarker for iron status and certain metabolic disorders, and to biotechnology, where it is an essential supplement in cell culture media for optimal cell growth. Additionally, transferrin and its receptor are being explored as targeted drug delivery vehicles, particularly for crossing the blood-brain barrier and treating central nervous system diseases.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Transferrin, Saturated, Tissue Culture Grade at -20°C.
Applications
Cell Culture Media, ELISA, Antisera Production, In Vitro Diagnostic, Protein Chemistry Research, Drug Delivery research, Iron Metabolism, Infection.
Citations/Publications
Cliff, T. S., et al., (2017), 'MYC Controls Human Pluripotent Stem Cell Fate Decisions through Regulation of Metabolic Flux', Cell Stem Cell 21: pp 502–516. Available at: https://doi.org/10.1016/j.stem.2017.08.018
Zhang, L., et al., (2020), 'Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State', Cell Stem Cell 27: pp 784–797. Available at: https://doi.org/10.1016/j.stem.2020.07.013
Singh, A. M., et al., (2020), 'Human beige adipocytes for drug discovery and cell therapy in metabolic diseases', NATURE COMMUNICATIONS 11: pp 2758. Available at: https://doi.org/10.1038/s41467-020-16340-3
Colunga, T., et al., (2019), 'Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair', Cell Reports 26: pp 2566–2579.e1–e10. Available at: https://doi.org/10.1016/j.celrep.2019.02.016
Chen, L., et al., (2020), 'Multipotent Vascular Progenitor Cells of the Mesothelium Lineage Generated from Human Pluripotent Stem Cells', STAR Protocols 1: pp 100031. Available at: https://doi.org/10.1016/j.xpro.2020.100031
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02787/
Shipped with ice packs
Gel Scan of Human Transferrin, Saturated, Tissue Culture Grade
| Fig. 1: SDS-PAGE Gel |
Verwendung: Nur für Forschungszwecke. Nicht zur Verwendung in diagnostischen oder therapeutischen Verfahren. Nicht für den menschlichen Gebrauch.
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