Human Plasmin (Plasma) Enzyme

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Product Overview, Sizes and Prices

 

Enzymes

Synonyms: Fibrinolysin, Fibrinase, Serum tryptase, Thrombolysin, Plasmin natural, EC 3.4.21.7, CAS# 9001-90-5.

Source: Human Plasma

Biological activity: ≥ 10 units/mg

Purity: ≥ 90 % (SDS-PAGE)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
4685.959.199 1 mg 350 €
4685.959.109 10 mg 2.275 €
4685.959.166 100 mg on request

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

Fibrinolysin, Fibrinase, Serum tryptase, Thrombolysin, Plasmin natural, EC 3.4.21.7, CAS# 9001-90-5.

 

Description of Human Plasmin (Plasma)

Human Plasmin from human plasma is an enzyme with a serine type endopeptidase activity and a molecular mass of 81 kDa. It has been prepared from streptokinase activated human plasma Plasminogen. Plasmin plays an important role in the fibrinolytic cascade, in inflammation processes and wound healing. It degrades fibrin, the main component of blood clots. Generally, Plasmin catalysis the hydrolysis of peptides, arginine and lysine esters and converts fibrin into soluble products. For the preferential cleavage at the carboxyl side of lysin and arginine it shows a higher selectivity than trypsin. Plasmin has been found to activate the lymphangiogenic growth factors VEGF-C and VEGF-D (Bradley et. al, PMID: 12963694), while it degrades VEGF165 (Künnapuu et.al PMID: 33672235).

 

Human Virus Test

FDA approved Plasma from each donor has been tested and found negative for antibodies to HIV-1, HIV-2, HCV, HBc, and non-reactive for HBsAg.

 

Biological Activity

The biological active is ≥ 10 units/mg. One unit is defined as the amount of enzyme that hydrolyzes one µmole of tosyl-Gly-Pro-Lys-pNA per minute at 25°C, pH 7.8. One Unit = 1.25 CU.

 

Reconstitution

We recommend a quick spin followed by addition of x µl water (de-ionized) to obtain a solution with xmg/ml. Mix gently to assure adequate homogenization. Do not vortex. This solution can be stored at 2-8°C for up to 1 week or in working aliquots at -20°C. For further dilution please use the lyophilization buffer. Working aliquots should be at the highest practical concentration.

 

Stability

The lyophilized protein is stable at room temperature for up to 1 month and at least until the lot specific expiry date if kept below -18°C. Reconstituted Plasmin should be stored in working aliquots at -20°C. Please avoid repeated freeze-thaw cycles.

 

Shipping symbol Shipped at room temperature

 

 

 

SDS-Page

<strong>Fig. 1</strong>: SDS-PAGE of Human Plasmin (Plasma) (10µg/lane). P<sub>red</sub> was reduced/heated, P<sub>non-red</sub> was not reduced/heated.

Fig. 1: SDS-PAGE of Human Plasmin (Plasma) (10µg/lane). Pred was reduced/heated, Pnon-red was not reduced/heated.

 

 

 

 

 

 

 

 

 

To buy Human Plasmin (Plasma) please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

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Errors, changes and availability excepted.

 

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500 € within Germany

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Content

 

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