Anti-Human TIE-1, bt (#6F12) (MAB) Monoclonal Antibody

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Product Overview, Sizes and Prices

 

Monoclonal Antibodies (MAB)

Synonyms: TIE1, TIE, JTK14

Source: Mouse

Clone: AB-7G23

Isotype: IgG1

Manufacturer:  Active Bioscience

Article No. Size Price  
1950.551.050 50 µg 230 €

 

 

Product Details

Synonyms

TIE1, TIE, JTK14

 

Description of Anti-Human TIE-1, bt (#6F12) (MAB)

Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.

 

Biological Activity

ELISA: Use at 1-15 µg/ml.

 

Reconstitution

Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

 

Shipping symbol Shipped at room temperature

 

 

 

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

To buy Anti-Human TIE-1, bt (#6F12) (MAB) please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

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Errors, changes and availability excepted.

 

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500 € within Germany

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