Anti-Human CCM-3 Polyclonal Antibody

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Product Overview, Sizes and Prices

 

Polyclonal Antibody (PAB)

Synonyms: PDCD10, CCM3, TFAR15, programmed cell death 10

Source: Rabbit

Clone: AB-Sbccju!JH

Manufacturer:  Active Bioscience

Article No. Size Price  
4386.852.100 100 µg 175 €
4386.852.200 200 µg 285 €

 

 

Product Details

Synonyms

PDCD10, CCM3, TFAR15, programmed cell death 10

 

Description of Anti-Human CCM-3

Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while down regulation of endogenous CCM3 results in increased formation of tube-like structures. Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death. Tyrosine kinase activity profiling suggests that CCM3 supports PDPK-1/Akt-mediated endothelial cell quiescence and survival (Schleider et al, Neurogenetics 12, 2011).

 

Biological Activity

Western Blot: Use 1-5 µg/ml

 

Reconstitution

Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

 

 

 

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Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500 € within Germany

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