Anti-Human CCM-3 Polyclonal Antibody

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+49 (0) 40 . 43 20 84 48 0

 

Product Overview, Sizes and Prices

 

Polyclonal Antibody (PAB)

Synonyms: PDCD10, CCM3, TFAR15, programmed cell death 10

Source: Rabbit

Clone: AB-Sbccju!JH

Manufacturer:  Active Bioscience

Article No.SizePrice 
4386.852.100 100 µg 175 €
4386.852.200 200 µg 285 €

 

 

Produktdetails

Synonyms

PDCD10, CCM3, TFAR15, programmed cell death 10

 

Description of Anti-Human CCM-3

Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while down regulation of endogenous CCM3 results in increased formation of tube-like structures. Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death. Tyrosine kinase activity profiling suggests that CCM3 supports PDPK-1/Akt-mediated endothelial cell quiescence and survival (Schleider et al, Neurogenetics 12, 2011).

 

Biological Activity

Western Blot: Use 1-5 µg/ml

 

Reconstitution

Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

 

Shipping Shipped at room temperature

 

 

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

To buy Anti-Human CCM-3 Polyclonal Antibody please click on the Shopping List Symbol right from the indicated price. This will add Anti-Human CCM-3 Polyclonal Antibody to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

 

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Errors, changes and availability excepted.

 

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500 € within Germany

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