Anti-Human Galectin-1 Polyclonal Antibody

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Product Overview, Sizes and Prices

 

Polyclonal Antibody (PAB)

Synonyms: LGALS1, GBP, GAL1

Source: Rabbit

Clone: AB-Sbccju!JH

Manufacturer:  Active Bioscience

Article No. Size Price  
1421.852.050 50 µg 210 €
1421.852.100 100 µg 175 €
1421.852.200 200 µg 290 €

 

 

Product Details

Synonyms

LGALS1, GBP, GAL1

 

Description of Anti-Human Galectin-1

Galectin-1, also known as L14, BHL and galaptin, is a monomeric or homodimeric prototype galectin that is expressed in a variety of cells and tissues including muscle, heart, liver, prostate, lymph nodes, spleen, thymus, placenta, testis, retina, macrophages, B cells, T cells, dendritic cells, and tumor cells. It preferentially binds laminin, fibronectin, 90K/Mac2BP, CD45, CD43, CD7, CD2, CD3, and ganglioside GM1. Galectin-1 modulates cell growth and proliferation, either positively or negatively, depending on the cell type and activation status. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes. It modulates cytokine secretion by inducing Th2 type cytokines and inhibiting proinflammatory cytokine production. Galectin1 can also modulate cel-lcell as well as cell-lmatrix interactions and depending on the cell type and developmental stage, promote cell attachment or detachment. Galectin-1 has immunosuppressive and antiinflammatory properties and has been shown to suppress acute and chronic inflammation and autoimmunity. Human and mouse galectin1 share about 88% amino acid sequence similarity.

 

Biological Activity

Western Blot: Use 1-5 µg/ml

 

Reconstitution

Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

 

 

 

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Payment Methods

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Shipping

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Free shipping for orders above 500 € within Germany

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