Anti-Human HGF Polyclonal Antibody

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Synonyms

HGF, SF, HGFB, HPTA, F-TCF, DFNB39

Description of Anti-Human HGF

HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (a-chain and ß-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The a-chain consists of 463 amino acid residues and four kringle domains. The ß-chain consists of 234 amino acid residues.

Biological Activity

Western Blot: Use 1-5 µg/ml

Reconstitution

Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

Shipped at room temperature