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Anti-Murine LYVE-1 (AG) Polyclonal Antibody
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Polyclonal Antibody (PAB) Synonyms: Lyve1, Xlkd1, Lyve-1, Crsbp-1, 1200012G08Rik Source: Rabbit Clone: AB-Sbccju!JH Manufacturer: |
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Active Bioscience
Produktdetails
Synonyms
Lyve1, Xlkd1, Lyve-1, Crsbp-1, 1200012G08Rik
Description of Anti-Murine LYVE-1 (AG)
LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Biological Activity
Western Blot: use at 2-5 µg/ml; FACS: use at 3-10 µg/ml; IF/IHC: applicable with cryo-sections.
Reconstitution
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Shipped at room temperature
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
