Bovine Calmodulin, High Purity

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	Proteins Synonyms: CaM, Phosphodiesterase 3′, 5′-cyclic nucleotide activator, CALM Biological Activity: > 250, 000 units/mg protein Source: Bovine Tissue Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 30 mM Hepes, pH 7.4, 1 mM CaCl 2, 0.1 mM DTT Manufacturer:  Athens Research & Technology	Article No. Size Price   16-BR-030112-HP-BOVINE-1MG 1 mg 315 € 16-BR-030112-HP-BOVINE-5MG 5 mg 1.175 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

CaM, Phosphodiesterase 3′, 5′-cyclic nucleotide activator, CALM

 

Description of Bovine Calmodulin, High Purity

Bovine Calmodulin, High Purity is a 16.5 kDa protein. Calmodulin from bovine brain is a highly conserved, multifunctional calcium-binding protein that plays a central role in cellular signaling across eukaryotic organisms. Structurally, it contains four EF-hand motifs that each bind a calcium ion, triggering conformational changes that enable calmodulin to interact with and regulate a vast array of target proteins, many of which cannot bind calcium directly. Through these interactions, calmodulin orchestrates essential physiological processes, including muscle contraction, metabolism, inflammation, apoptosis, intracellular movement, nerve growth, and both short- and long-term memory formation. Mutations in calmodulin genes (CALM1–3) can cause calmodulinopathies, a group of severe inherited arrhythmia syndromes such as long QT syndrome and catecholaminergic polymorphic ventricular tachycardia, often manifesting in childhood and sometimes leading to sudden cardiac death2. In research and biotechnology, bovine brain calmodulin is widely used in vitro to study calcium signaling pathways, protein interactions, and drug screening due to its purity and functional conservation.

 

Source

Prepared from tissue collected in the contiguous United States from animals under 30 months of age at a USDA-inspected facility. Animals were inspected ante mortem and found free from obvious signs of infectious and contagious diseases.

 

Biological Activity

> 250, 000 units/mg protein. One unit is defined as the amount of calmodulin that will give rise to 50% of the maximal enzyme activation of a standard level of activator-deficient calcineurin.

 

Storage

For long term, store Bovine Calmodulin, High Purity at ≤ -20°C.

 

Applications

Inflammation.

 

Citations/Publications

NCBI: https://www.ncbi.nlm.nih.gov/protein/P62157

 

Shipped with ice packs

 

Gel Scan of Bovine Calmodulin, High Purity

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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