EN
Bovine S-100aa
Native, whole molecule
Product Overview, Sizes and Prices | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteins Synonyms: S-100aa Calcium Binding Protein, S-100 protein alpha chain S-100 protein subunit alpha Source: Bovine Tissue Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 50 mM Tris-HCl, pH 7.5, 50 mM NaCl, 100 µM DTT Manufacturer: |
|
|||||||||||||
Athens Research & Technology
Produktdetails
Synonyms
S-100aa Calcium Binding Protein, S-100 protein alpha chain S-100 protein subunit alpha
Description of Bovine S-100aa
Bovine S-100aa is a 6.5 kDa protein. S-100αα (S-100aa) from bovine brain is a low molecular weight, cytoplasmic, calcium-binding protein belonging to the S100 family, which is characterized by the presence of EF-hand calcium-binding motifs. Structurally, S-100αα is a homodimer composed of two alpha subunits, distinct from the beta-beta (S-100ββ) and alpha-beta (S-100αβ) forms found in nervous tissue. Its conformation and function are modulated by calcium and, to a lesser extent, by other ions such as potassium, reflecting its role in responding to changes in the cellular environment. Functionally, S-100αα participates in the regulation of various intracellular activities, including cell proliferation, differentiation, and cytoskeletal dynamics, often through interactions with target proteins in a calcium-dependent manner. It is predominantly expressed in astroglial cells and is involved in maintaining neural homeostasis. Aberrant expression or release of S-100 proteins, including S-100αα, has been linked to neurological diseases such as Alzheimer's disease, stroke, and traumatic brain injury, where their serum levels serve as sensitive biomarkers of brain damage and disease progression. In research and clinical applications, S-100αα is widely used as a marker for central nervous system injury and as a tool for studying calcium-mediated signaling pathways in neurobiology. Its measurement aids in diagnosis, prognosis, and monitoring of neurological disorders and has potential utility in cancer and inflammatory disease research due to the broader roles of S100 proteins in cell regulation and disease pathogenesis.
Source
Prepared from tissue collected in the contiguous United States from animals under 30 months of age at a USDA-inspected facility. Animals were inspected ante mortem and found free from obvious signs of infectious and contagious diseases.
Storage
For long term, store Bovine S-100aa at -20°C.
Applications
Alzheimer's, Stroke, In Vitro Diagnostics, Brain Injury, Cancer, Inflammation.
Citations/Publications
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02639
Shipped with ice packs
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
To buy Bovine S-100aa please click on the Shopping List Symbol right from the indicated price. This will add Bovine S-100aa to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.
For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
