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Bovine S-100b
Native, whole molecule
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Proteins Synonyms: S-100b Calcium Binding Protein, S-100 protein beta chain S-100 protein subunit beta Source: Bovine Tissue Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 50 mM Tris-HCl, pH 7.5, 50 mM NaCl, 100 µM DTT Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
S-100b Calcium Binding Protein, S-100 protein beta chain S-100 protein subunit beta
Description of Bovine S-100b
Bovine S-100b is a 6 kDa protein. S-100b from bovine brain is a calcium-binding protein predominantly expressed in astrocytes and select neuronal populations. Structurally, it forms a homodimer (beta-beta) and plays crucial roles in neurodevelopment, including the differentiation and maturation of astrocytes and oligodendrocytes, as well as promoting neurite outgrowth and protecting neurons from apoptosis at physiological (low) concentrations. S-100b is also involved in maintaining blood–brain barrier integrity and modulating synaptic plasticity and memory formation. Pathologically, elevated S-100b levels are associated with a range of neurological diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, epilepsy, traumatic brain injury, and cerebrovascular disorders. At high concentrations, S-100b acts as a proinflammatory cytokine, exacerbating neuroinflammation and neuronal damage, particularly through interaction with the RAGE receptor. It is also a recognized biomarker for brain injury and is widely used in clinical practice for the early diagnosis and prognosis of traumatic brain injury, as well as in monitoring disease progression in malignant melanoma due to its secretion by tumor cells. In research and diagnostics, S-100b’s measurement in serum or cerebrospinal fluid serves as a sensitive marker for neural distress, brain injury, and certain cancers, supporting both clinical decision-making and experimental studies on neuroinflammation and neurodegeneration.
Source
Prepared from tissue collected in the contiguous United States from animals under 30 months of age at a USDA-inspected facility. Animals were inspected ante mortem and found free from obvious signs of infectious and contagious diseases.
Storage
For long term, store Bovine S-100b at -20°C.
Applications
Alzheimer’s disease, Parkinson’s, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Epilepsy, Traumatic brain injury, Cerebrovascular disorders, Cancer, In Vitro Diagnostics.
Citations/Publications
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02638
Shipped with ice packs
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
