Cynomolgus Monkey Albumin

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	Proteins Synonyms: Alb Source: Cynomolgus Monkey Plasma Physical State: Salt-free lyophilized solid Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-011202-CM-1MG 1 mg 155 € 16-16-011202-CM-10MG 10 mg 455 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

Alb

 

Description of Cynomolgus Monkey Albumin

Cynomolgus Monkey Albumin is a 66 kDa protein. Albumin constitutes 60% of plasma proteins and exhibits exceptional structural stability due to its 17 disulfide bonds and conserved N-glycosylation. Beyond maintaining 80% of plasma oncotic pressure to prevent vascular fluid leakage, albumin binds and transports hydrophobic ligands-including fatty acids, steroids, thyroid hormones, calcium ions, and over 90% of circulating drugs-via its dynamic binding pockets. Its free Cys34 residue confers antioxidant properties by scavenging reactive oxygen species. Hypoalbuminemia (<3.5 g/dL) arises from hepatic dysfunction (cirrhosis, hepatitis), renal protein loss (nephrotic syndrome), chronic inflammation, or malnutrition. Clinically, it manifests as edema, ascites, and impaired drug efficacy due to reduced ligand binding. Conversely, glycated albumin contributes to diabetic complications by promoting vascular endothelial dysfunction3. Therapeutically, human serum albumin (HSA) has been administered since 1941 for hypovolemia and burns, with modern 5% and 25% solutions managing ARDS and cardiopulmonary bypass. With a 19-day circulatory half-life, albumin stabilizes cell culture media.

 

Source

Cynomolgus Monkey plasma was obtained from healthy animals of US origin and under the care of a registered veterinarian. Prepared from donor monkeys that have been individually tested for B-Virus (Herpes Virus Simiae) and found to be negative.

 

Storage

For long term, store Cynomolgus Monkey Albumin at ≤ -20°C.

 

Applications

Cell Culture Media, In Vitro Diagnostic, Calibrators, Control, Antisera Production, Protein Chemistry, Therapeutics Research.

 

Citations/Publications

Liu, H., et al., (2021), 'An engineered IL-21 with half-life extension enhances anti-tumor immunity as a monotherapy or in combination with PD-1 or TIGIT blockade', International Immunopharmacology 101: pp 108307. Available at: https://doi.org/10.1016/j.intimp.2021.108307
Tamburini, P., et al., (2024), 'Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration', MABS, 16(1): pp 2415060. Available at: https://doi.org/10.1080/19420862.2024.2415060
Jindal, S., et al., (2024), 'Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration', Molecular Immunology 165: pp 29–41. Available at: https://doi.org/10.1016/j.molimm.2023.12.004
NCBI: https://www.ncbi.nlm.nih.gov/protein/190358749

 

Shipped with ice packs

 

Gel Scan of Cynomolgus Monkey Albumin

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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