EN
Cynomolgus Monkey Transferrin
Native, whole molecule
Product Overview, Sizes and Prices | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteins Synonyms: Trf, Siderophilin, Serotransferrin, Beta-1 metal-binding globulin, TRF, TF, PRO1400, PRO1557 Source: Cynomolgus Monkey Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 20 mM Na Phosphate, pH 7.4, and 150 mM NaCl Manufacturer: |
|
|||||||||||||||||
Athens Research & Technology
Produktdetails
Synonyms
Trf, Siderophilin, Serotransferrin, Beta-1 metal-binding globulin, TRF, TF, PRO1400, PRO1557
Description of Cynomolgus Monkey Transferrin
Cynomolgus Monkey Transferrin is a 80 kDa protein. Transferrin is a multifunctional monomeric glycoprotein primarily synthesized in the liver and found abundantly in plasma, where it plays a central role in iron metabolism and homeostasis. Each transferrin molecule can reversibly bind two ferric (Fe³⁺) ions with high affinity, facilitating the safe transport and regulated distribution of iron from absorption sites in the gut and macrophages to tissues throughout the body, especially to the bone marrow for hemoglobin synthesis. This iron delivery is mediated through transferrin receptors on cell surfaces, enabling receptor-mediated endocytosis and precise cellular iron uptake. Beyond iron transport, transferrin possesses significant antimicrobial properties by sequestering free iron, thereby limiting its availability to bacteria and fungi-a process that contributes to innate immune defense and exhibits bacteriostatic and fungistatic effects. Clinically, altered transferrin levels are linked to various conditions: increases are seen in iron-deficiency anemia and pregnancy, while decreases occur in inflammatory diseases, nephrotic syndrome, hypoproteinemia, and rare genetic disorders like atransferrinemia, which causes severe anemia and iron overload in tissues. Transferrin’s applications extend to clinical diagnostics, where it serves as a biomarker for iron status and certain metabolic disorders, and to biotechnology, where it is an essential supplement in cell culture media for optimal cell growth. Additionally, transferrin and its receptor are being explored as targeted drug delivery vehicles, particularly for crossing the blood-brain barrier and treating central nervous system diseases.
Source
Cynomolgus Monkey plasma was obtained from healthy animals of US origin and under the care of a registered veterinarian. Prepared from donor monkeys that have been individually tested for B-Virus (Herpes Virus Simiae) and found to be negative
Storage
For long term, store Cynomolgus Monkey Transferrin at -20°C.
Applications
ELISA, Antisera Production, In Vitro Diagnostic, Protein Chemistry Research, Drug Delivery research, Iron Metabolism, Infection.
Shipped with ice packs
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
To buy Cynomolgus Monkey Transferrin please click on the Shopping List Symbol right from the indicated price. This will add Cynomolgus Monkey Transferrin to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.
For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
