Human 4-1BB Receptor recombinant Protein

Phone: +49 (0) 40 . 43 20 84 48 0

E-Mail: info@active-bioscience.de

 

Product Overview, Sizes and Prices

 

Protein

Synonyms: Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor T-cell, antigen 4-1BB homolog, T-cell antigen ILA, CD137 antigen, CDw137, ILA, 4-1BB, MGC2172, 4-1BBR, TNFRSF9.

Source: E. coli

Purity: ≥ 98 % (SDS-PAGE, RP-HPLC)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1167.950.005 5 µg 60 €
1167.950.020 20 µg 159 €
1167.950.199 1 mg 2290 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor T-cell, antigen 4-1BB homolog, T-cell antigen ILA, CD137 antigen, CDw137, ILA, 4-1BB, MGC2172, 4-1BBR, TNFRSF9.

 

Description of Human 4-1BB Receptor

Recombinant human soluble 4-1BB receptor is a 17.7 kDa protein consisting of 167 amino acid residues, which contains the cysteine rich TNFR-like extracellular domain of 4-1BB receptor. 4-1BB receptor, a member of the TNFR superfamily of receptors, is mainly expressed on the surface of T cells, but also in B cells, monocytes, and various transformed cell lines. 4-1BB receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain.

 

Biological Activity

The activity was determined by the inhibition of 4-1BB ligand mediated stimulation of IL-8 production by human PBMC. Results: 90% inhibition using 1µg for both 4-1BB ligand and 4-1BB receptor.

 

Reconstitution

We recommend a quick spin followed by reconstitution in sterile water to a concentration of at least 100 µg/ml, which can then be further diluted to other aqueous solutions. Do not vortex.

 

Stability

Lyophilized 4-1BB Receptor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution 4-1BBR should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid repeated freeze-thaw cycles.

 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Glu-Arg-Thr-Arg.

 

 

 

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Payment Methods

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Shipping

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