Human 4-1BB Receptor recombinant Protein
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Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor T-cell, antigen 4-1BB homolog, T-cell antigen ILA, CD137 antigen, CDw137, ILA, 4-1BB, MGC2172, 4-1BBR, TNFRSF9.
Description of Human 4-1BB Receptor
Recombinant human soluble 4-1BB receptor is a 17.7 kDa protein consisting of 167 amino acid residues, which contains the cysteine rich TNFR-like extracellular domain of 4-1BB receptor. 4-1BB receptor, a member of the TNFR superfamily of receptors, is mainly expressed on the surface of T cells, but also in B cells, monocytes, and various transformed cell lines. 4-1BB receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain.
The activity was determined by the inhibition of 4-1BB ligand mediated stimulation of IL-8 production by human PBMC. Results: 90% inhibition using 1µg for both 4-1BB ligand and 4-1BB receptor.
We recommend a quick spin followed by reconstitution in sterile water to a concentration of at least 100 µg/ml, which can then be further diluted to other aqueous solutions. Do not vortex.
Lyophilized 4-1BB Receptor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution 4-1BBR should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA, order number: 2835.955.xyz or 2835.958.xyz, or BSA, order number: 2835.919.xyz). Please avoid repeated freeze-thaw cycles.
Amino Acid Sequence
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Glu-Arg-Thr-Arg.
Shipped at room temperature
To buy Human 4-1BB Receptor please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human 4-1BB Receptor is an alternative for the no longer available Promokine 4-1BB sReceptor (CD137), human, recombinant (C-66551).
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