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Human Albumin
Native whole molecule
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Proteins Synonyms: Alb, HSA, FDAHT, PRO0883, PRO0903, PRO1341 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Salt-free lyophilized solid Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
Alb, HSA, FDAHT, PRO0883, PRO0903, PRO1341
Description of Human Albumin
Human Albumin is a 66 kDa protein. Albumin constitutes 60% of plasma proteins and exhibits exceptional structural stability due to its 17 disulfide bonds and conserved N-glycosylation. Beyond maintaining 80% of plasma oncotic pressure to prevent vascular fluid leakage, albumin binds and transports hydrophobic ligands-including fatty acids, steroids, thyroid hormones, calcium ions, and over 90% of circulating drugs-via its dynamic binding pockets. Its free Cys34 residue confers antioxidant properties by scavenging reactive oxygen species. Hypoalbuminemia (<3.5 g/dL) arises from hepatic dysfunction (cirrhosis, hepatitis), renal protein loss (nephrotic syndrome), chronic inflammation, or malnutrition. Clinically, it manifests as edema, ascites, and impaired drug efficacy due to reduced ligand binding. Conversely, glycated albumin contributes to diabetic complications by promoting vascular endothelial dysfunction3. Therapeutically, human serum albumin (HSA) has been administered since 1941 for hypovolemia and burns, with modern 5% and 25% solutions managing ARDS and cardiopulmonary bypass. With a 19-day circulatory half-life, albumin stabilizes cell culture media.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Albumin at ≤ -20°C.
Applications
Cell Culture Media, In Vitro Diagnostic, Calibrators, Control, Antisera Production, Protein Chemistry, Therapeutics Research.
Citations/Publications
Zhang, N., et al., (2018) 'Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management', Drug Metab Dispos 46: pp 823–834. Available at https://doi.org/10.1124/dmd.117.079673
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02768
Shipped with ice packs
Gel Scan of Human Albumin
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
