Human Alpha 1 Acid Glycoprotein (A1AGP)

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	Proteins Synonyms: A1AGP, AGP, AAG, Orosomucoid, ORM Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Salt-free lyophilized solid Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-010700-1MG 1 mg 65 € 16-16-010700-10MG 10 mg 325 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

A1AGP, AGP, AAG, Orosomucoid, ORM

 

Description of Human Alpha 1 Acid Glycoprotein (A1AGP)

Human Alpha 1 Acid Glycoprotein (A1AGP) is a ~45000 Da under Reducing and Non-Reducing Conditions by SDS-PAGE protein. Alpha-1 acid glycoprotein (AGP), a glycoprotein constituting 55–140 mg/dL of plasma, features five N-linked glycan chains comprising 40–45% of its mass, including sialylated bi-/tri-/tetra-antennary structures critical for ligand interactions. Thus contributing to its use as a standard for glycosylation studies. As a major acute-phase reactant, AGP surges up to 5-fold during inflammation, synergizing with haptoglobin to diagnose acute inflammation and differentiate hepatic vs. obstructive jaundice. Its glycosylation profile shifts in pathologies: acute inflammation increases bi-antennary and α1, 3-fucosylated glycans, while chronic states enhance tri-/tetra-antennary fucosylation. AGP binds progesterone 15× more avidly than albumin and complexes with vitamin B-12 when sialic acid-deficient, influencing drug pharmacokinetics and nutrient transport. AGP modulates immunity via TLR-2/4 interactions, exacerbating TLR-2-mediated sepsis mortality while inhibiting LPS-driven NETosis. Dysregulated AGP correlates with rheumatoid arthritis, Waldenström macroglobulinemia, and metastatic cancers, where glycoforms alter platelet aggregation and neutrophil adhesion. The AGP:haptoglobin ratio aids in diagnosing bone marrow disorders and hemolytic anemia, reflecting erythropoietic activityTherapeutically, AGP’s drug-binding capacity informs personalized dosing for basic drugs (e.g., chlorpromazine), while engineered glycoforms are explored for targeted anti-inflammatory therapies.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Alpha 1 Acid Glycoprotein (A1AGP) at ≤ -20°C.

 

Applications

Protein Glycosylation studies, In Vitro Diagnostics, Antisera Production.

 

Citations/Publications

Decurtins, W., et al., (2018) 'Automated screening for small organic ligands using DNA-encoded chemical libraries', Nature Protocols, 11: pp 764–780 (2016). Available at doi:10.1038/nprot.2016.039 
Zhong, C., et al., (2018) 'Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species', Acta Pharmacologica Sinica, 39: pp 1048–1063. Available at doi: 10.1038/aps.2017.199 
Zhang, N., et al., (2018) 'Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management', Drug Metab Dispos 46: pp 823–834. Available at https://doi.org/10.1124/dmd.117.079673
van Schaick, G., et al., (2024) 'Anion Exchange Chromatography–Mass Spectrometry to Characterize Proteoforms of Alpha-1-Acid Glycoprotein during and after Pregnancy', Journal of Proteome Research, 23(7): pp 2431-2440. Available at DOI: 10.1021/acs.jproteome.4c00107 

NCBI: https://www.ncbi.nlm.nih.gov/protein/P02763/

 

Shipped with ice packs

 

Gel Scan of Human Alpha 1 Acid Glycoprotein (A1AGP)

Fig. 1: SDS-PAGE Gel

 

 

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Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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