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Human Alpha 1 Antichymotrypsin
Native whole molecule
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Proteins Synonyms: A1X, ACT, AACT, SerpinA3 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 20 mM Tris, pH 7.4, with 150 mM NaCl Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
A1X, ACT, AACT, SerpinA3
Description of Human Alpha 1 Antichymotrypsin
Human Alpha 1 Antichymotrypsin is a 64 kDa protein. Alpha 1-antichymotrypsin (ACT) is an acute-phase plasma glycoprotein encoded by the SERPINA3 gene, primarily produced in the liver. As a member of the serpin superfamily, ACT functions by inhibiting chymotrypsin-like serine proteases, including neutrophil cathepsin G and mast cell chymases. This protective mechanism prevents tissue damage from proteolytic enzymes, particularly in the lower respiratory tract. Normal serum levels range from 25-40mg/dL. During inflammatory processes, ACT concentration increases proportionally to the extent of tissue damage, with levels declining as inflammation resolves. ACT is significantly involved in Alzheimer's disease pathology, where it's overexpressed in astrocytes surrounding amyloid plaques, enhancing amyloid-beta fibrillization and inducing tau hyperphosphorylation. It's also elevated in rheumatoid arthritis, Crohn's disease, ulcerative colitis, and following burn injuries. Clinically, the PSA-ACT complex serves as a valuable biomarker for prostate cancer, indicating tumor mass and clinical staging.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Alpha 1 Antichymotrypsin at ≤ -20°C.
Applications
Proteolytic Inhibition studies, Alzheimers research, Prostate Cancer Research. In Vitro Diagnostics, Antisera Production.
Citations/Publications
Laberge, A., et al., (2019) 'α‐2‐Macroglobulin induces the shedding of microvesicles from cutaneous wound myofibroblasts', J Cell Physiol., 234: pp 11369–11379. Available at DOI: 10.1002/jcp.27794
Domain, R., et al., (2024) 'Pharmacological inhibition of cathepsin S and of NSPs-AAP-1 (a novel, alternative protease driving the activation of neutrophil serine proteases)', Biochemical Pharmacology, 229: pp 116114. Available at https://doi.org/10.1016/j.bcp.2024.116114
NCBI: https://www.ncbi.nlm.nih.gov/protein/P01011
Shipped with ice packs
Gel Scan of Human Alpha 1 Antichymotrypsin
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
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