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Human Alpha 2 HS Glycoprotein
Native whole molecule
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Proteins Synonyms: Alpha-2-Z-globulin Ba-alpha-2-glycoprotein Fetuin-A, AHSG, A2HS, AHS, FETUA, HSGA Source: Human Plasma Purity: ≥ 90% by SDS-PAGE Physical State: Lyophilized from 20 mM Tris-HCl, pH 8.0, with 200 mM NaCl Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
Alpha-2-Z-globulin Ba-alpha-2-glycoprotein Fetuin-A, AHSG, A2HS, AHS, FETUA, HSGA
Description of Human Alpha 2 HS Glycoprotein
Human Alpha 2 HS Glycoprotein is a 49 kDa protein. Alpha 2 HS glycoprotein (AHSG), also known as fetuin-A, is a heterodimeric plasma glycoprotein found in human serum at approximately 60 mg per 100 ml. AHSG is predominantly synthesized in the liver, with limited production in adipocytes and monocytes. AHSG functions as a negative acute-phase reactant, decreasing during inflammatory states. AHSG exhibits multifaceted functionality, regulating calcium metabolism, osteogenesis, and insulin signaling pathways. It inhibits ectopic calcification by forming soluble complexes with calcium and phosphate, mediates inflammatory processes, and promotes wound healing. Clinically, AHSG concentrations are reduced in cancer patients, though its role varies by cancer type. AHSG levels are positively correlated with gestational diabetes and unexplained infertility, while negatively affecting neonatal skeletal development. Higher concentrations appear in peritoneal fluids of endometriosis patients. Elevated levels are also observed in both small- and large-for-gestational-age infants. AHSG shows potential as a diagnostic biomarker for endometriosis. gestational diabetes complications, and fetal growth abnormalities, offering promising applications in clinical settings.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Alpha 2 HS Glycoprotein at ≤ -20°C.
Applications
In Vitro Diagnostic, Standard for Cell Based Assays.
Citations/Publications
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02765
Shipped with ice packs
Gel Scan of Human Alpha 2 HS Glycoprotein
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
