EN
Human Alpha 2 Macrglobulin (A2M)
Native whole molecule, biologically active protease inhibitor
Product Overview, Sizes and Prices | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteins Synonyms: α2-Macroglobulin, Alpha 2 Macroglobulin-Slow Form (Normal/Active), α2M, A2M, A2MD, CPAMD5, FWP007, S863-7, S-A2M Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 30 mM Na Phosphate, pH 7.0 , and 1 mg glycine per 1 mg Alpha 2 Macroglobulin. Manufacturer: |
|
|||||||||||||||||||||
Athens Research & Technology
Produktdetails
Synonyms
α2-Macroglobulin, Alpha 2 Macroglobulin-Slow Form (Normal/Active), α2M, A2M, A2MD, CPAMD5, FWP007, S863-7, S-A2M
Description of Human Alpha 2 Macrglobulin (A2M)
Human Alpha 2 Macrglobulin (A2M) is a 725 kDa protein. Alpha-2-macroglobulin (A2M) is a large (725 KDa) plasma glycoprotein found at concentrations of 240 mg/100 ml in men and 290 mg/100 ml in women. This versatile protein functions through a unique "venus-flytrap" mechanism, inhibiting proteases of all catalytic types by forming a tetrameric cage around them. Beyond protease inhibition, A2M binds and transports cytokines, growth factors, zinc, and damaged proteins. It promotes cell migration, enhances immune function by facilitating antigen processing, and stimulates lymphocyte regeneration in irradiated subjects. A2M levels increase in nephrotic syndrome, liver cirrhosis, diabetes, and severe burn. Conversely, levels decrease in acute pancreatitis, hyperfibrinolytic states, and septicemia. Research indicates A2M's involvement in Alzheimer's disease pathology through binding and clearing amyloid-beta peptides. Clinically, A2M shows promise as a therapeutic agent for osteoarthritis, where it inhibits cartilage-degrading enzymes.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Alpha 2 Macrglobulin (A2M) at -20°C.
Applications
Enzyme Studies, ELISA, Antigen for Antibody production, IVD Antigens, Calibrators & Controls, Protein Chemistry Research, Biotherapeutics Studies.
Citations/Publications
Sochaj-Gregorczyk, A., et al. (2020) 'Plasmin inhibition by bacterial serpin: Implications in gum disease', The FASEB Journal., 34: pp.619–630. Available at: https://doi.org/10.1096/fj.201901490RR
Kirsipuu, T., et al. (2020) 'Copper(II)-binding equilibria in human blood', Scientific Reports., 10: pp. 5686. https://doi.org/10.1038/s41598-020-62560-4
Laberge, A., et al., (2021) 'Shedding of proangiogenic microvesicles from hypertrophic scar myofibroblasts', Experimental Dermatology, 30: pp.112–120. Available at: https://doi.org/10.1111/exd.14178
Laberge, A., et al., (2019) 'α‐2‐Macroglobulin induces the shedding of microvesicles from cutaneous wound myofibroblasts', J Cell Physiol., 234: pp. 11369–11379. Available at: https://doi.org/10.1002/jcp.27794
Dang, M.C., et al., (2025) 'Optimization of the Entropy-Based Wavelet Method for Removing Strong RF and AC Interferences in a Charge Detection Linear Ion Trap Mass Spectrometer', Anal. Chem., 97: pp. 5066−5076. Available at: https://doi.org/10.1021/acs.analchem.4c06069
NCBI: https://www.ncbi.nlm.nih.gov/protein/P01023
Shipped with ice packs
Gel Scan of Human Alpha 2 Macrglobulin (A2M)
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
To buy Human Alpha 2 Macrglobulin (A2M) please click on the Shopping List Symbol right from the indicated price. This will add Human Alpha 2 Macrglobulin (A2M) to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.
For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
