Human Alpha 2 Macroglobulin (A2M), Fast Form

1. Home
2. Proteins
3. Human Proteins

Product Overview, Sizes and Prices
	Proteins Synonyms: α2-Macroglobulin, F-α2M, F-A2M, A2MD, CPAMD5, FWP007, S863-7, F-A2M Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 100 mM Na Phosphate, pH 7.2 Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-012013-FF-500UG 500 µg 165 € 16-16-012013-FF-1MG 1 mg 250 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

α2-Macroglobulin, F-α2M, F-A2M, A2MD, CPAMD5, FWP007, S863-7, F-A2M

 

Description of Human Alpha 2 Macroglobulin (A2M), Fast Form

Human Alpha 2 Macroglobulin (A2M), Fast Form is a 725 kDa protein. Alpha 2 Macroglobulin, Fast Form (F-A2M) arises from structural changes in the Slow Form (S-A2M) after protease entrapment or cleavage of its thiol ester bond. Unlike S-A2M, which inhibits proteases via a "snap-trap" mechanism, F-A2M loses protease-inhibitory capacity and undergoes rapid hepatic clearance (half-life: 2–4 minutes). While F-A2M constitutes only 0.17–0.7% of total plasma A2M in healthy adults, its levels rise in conditions marked by protease activation, such as acute pancreatitis (linked to disease severity), sepsis, and multiple sclerosis. F-A2M serves as a biomarker for protease-driven pathologies, with elevated levels reflecting systemic inflammation or tissue damage. It also shows potential in neurodegenerative diseases, where it may inhibit amyloid fibril formation in Alzheimer’s and prion disorders by binding misfolded proteins. Clinically, F-A2M detection aids in monitoring protease activation in sepsis or artificial medical surfaces, while its cytokine-binding properties hint at therapeutic applications for inflammatory conditions.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Alpha 2 Macroglobulin (A2M), Fast Form at -20°C.

 

Applications

Enzyme Studies, ELISA, Antigen for Antibody production, IVD Antigens, Calibrators & Controls, Protein Chemistry Research, Biotherapeutics Studies.

 

Citations/Publications

Kirsipuu, T., et al., (2020), 'Copper(II)-binding equilibria in human blood', Scientific Reports, 10: pp 5686. Available at: https://doi.org/10.1038/s41598-020-62560-4
NCBI: https://www.ncbi.nlm.nih.gov/protein/P01023

 

Shipped with ice packs

 

Gel Scan of Human Alpha 2 Macroglobulin (A2M), Fast Form

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

To buy Human Alpha 2 Macroglobulin (A2M), Fast Form please click on the Shopping List Symbol right from the indicated price. This will add Human Alpha 2 Macroglobulin (A2M), Fast Form to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

 

For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.