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Human Alpha 2 Macroglobulin (A2M), Low Endotoxin Level
Native whole molecule, biologically active protease inhibitor. Low endotoxin Level product
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Proteins Synonyms: α2-Macroglobulin, Alpha 2 Macroglobulin-Slow Form (Normal/Active), α2M, A2M, A2MD, CPAMD5, FWP007, S863-7, S-A2M Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Endotoxin Level: ≤1 EU/mg Physical State: Lyophilized from 30 mM Na Phosphate, pH 7.0 , and 1 mg glycine per 1 mg Alpha 2 Macroglobu Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
α2-Macroglobulin, Alpha 2 Macroglobulin-Slow Form (Normal/Active), α2M, A2M, A2MD, CPAMD5, FWP007, S863-7, S-A2M
Description of Human Alpha 2 Macroglobulin (A2M), Low Endotoxin Level
Human Alpha 2 Macroglobulin (A2M), Low Endotoxin Level is a 725 kDa protein. Alpha-2-macroglobulin (A2M) is a large (725 KDa) plasma glycoprotein found at concentrations of 240 mg/100 ml in men and 290 mg/100 ml in women. This versatile protein functions through a unique "venus-flytrap" mechanism, inhibiting proteases of all catalytic types by forming a tetrameric cage around them. Beyond protease inhibition, A2M binds and transports cytokines, growth factors, zinc, and damaged proteins. It promotes cell migration, enhances immune function by facilitating antigen processing, and stimulates lymphocyte regeneration in irradiated subjects. A2M levels increase in nephrotic syndrome, liver cirrhosis, diabetes, and severe burn. Conversely, levels decrease in acute pancreatitis, hyperfibrinolytic states, and septicemia. Research indicates A2M's involvement in Alzheimer's disease pathology through binding and clearing amyloid-beta peptides. Clinically, A2M shows promise as a therapeutic agent for osteoarthritis, where it inhibits cartilage-degrading enzymes.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Alpha 2 Macroglobulin (A2M), Low Endotoxin Level at -20°C.
Applications
Enzyme Studies, ELISA, Antigen for Antibody production, IVD Antigens, Calibrators & Controls, Protein Chemistry Research, Biotherapeutics Studies, Cell Based Assays, Animal Studies.
Citations/Publications
NCBI: https://www.ncbi.nlm.nih.gov/protein/P01023
Shipped with ice packs
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
