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Human Angiotensinogen
Native whole molecule, precursor to angiotensin
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Proteins Synonyms: Hypertensinogen, Renin substrate, AGT, SERPIN A8 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 30 mM sodium phosphate, pH 6.8 Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
Hypertensinogen, Renin substrate, AGT, SERPIN A8
Description of Human Angiotensinogen
Human Angiotensinogen is a 55000-65000 Da protein. Angiotensinogen (AGT), a glycoprotein circulating at 2.8–7.1 mg/100 mL in plasma, serves as the precursor for all angiotensin peptides in the renin-angiotensin system (RAS), a critical regulator of blood pressure, fluid balance, and electrolyte homeostasis. Primarily synthesized by the liver, AGT is also produced in the brain, kidneys, adipose tissue, and arterial walls. During pregnancy, total AGT levels surge fourfold, while AGT increases 20-fold, becoming predominant in amniotic fluid (80%). AGT’s structural dynamics involve redox-sensitive disulfide bonds (Cys18-Cys138) and glycosylation, which modulate renin’s access to its cleavage site. As a non-inhibitory SERPIN, AGT lacks protease-inhibitory activity but undergoes conformational changes upon renin binding, releasing angiotensin I (AngI). Subsequent processing yields vasoactive peptides (AngII, Ang1-7, etc.), influencing vascular tone, inflammation, and fibrosis. Plasma AGT levels are upregulated by corticosteroids, estrogen, thyroid hormones, and AngII. Clinically, AGT polymorphisms (e.g., M235T) correlate with hypertension, preeclampsia, and cardiovascular diseases. Elevated AGT in pregnancy associates with gestational hypertension and preeclampsia. Emerging therapies target AGT via antisense oligonucleotides or siRNA to attenuate RAS activity, offering novel approaches for hypertension and heart failure. AGT’s form also serves as a biomarker for pregnancy-related hypertensive disorders.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Angiotensinogen at -20°C.
Applications
ELISA Standard & Calibrator, Hypertension research, In Vitro Diagnostic.
Citations/Publications
Bennink, H. J. T. C., et al., (2018), 'A Dose-Escalating Study With the Fetal Estrogen Estetrol in Healthy Men', J Clin Endocrinol Metab, 103(9): pp. 3239–3249. Available at: doi: 10.1210/jc.2018-00147.
NCBI: https://www.ncbi.nlm.nih.gov/protein/P01019
Shipped with ice packs
Gel Scan of Human Angiotensinogen
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
