Human Apolactoferrin

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	Proteins Synonyms: ApoLF, ApoLFT, Apolactotransferrin, Growth-inhibiting protein 12 Talalactoferrin Source: Human Milk Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 50 mM Tris-HCl, pH 8.0, with 0.2 M NaCl Manufacturer:  Athens Research & Technology	Article No. Size Price   16-13-A20103-5MG 5 mg 185 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

ApoLF, ApoLFT, Apolactotransferrin, Growth-inhibiting protein 12 Talalactoferrin

 

Description of Human Apolactoferrin

Human Apolactoferrin is a 82.4 kDa protein. Apolactoferrin, the iron-free isoform of lactoferrin, retains the iron-binding capacity of its parent protein while exhibiting distinct functional properties. Constituting >90% of lactoferrin in human milk, this glycoprotein plays critical roles in neonatal immunity and nutrient regulation. Unlike iron-saturated hololactoferrin, apolactoferrin exerts bacteriostatic effects through dual mechanisms: iron sequestration (depriving pathogens of essential nutrients) and direct microbial membrane disruption via cationic peptides like lactoferricin. Its synergy with secretory IgA enhances intestinal barrier function in breastfed infants, inhibiting pathogens such as Escherichia coli and Streptomyces scabiei. Clinically, apolactoferrin contributes to reducing necrotizing enterocolitis (NEC) in preterm infants by modulating gut microbiota and suppressing pro-inflammatory cytokines like TNF-α. It also shows promise in managing iron-deficiency anemia, as its iron-free state facilitates dietary iron absorption by competitively binding dietary inhibitors (e.g., phytates)6. Elevated apolactoferrin levels correlate with reduced sepsis risk in neonates, while its anti-amyloid activity in Alzheimer’s models suggests neuroprotective potential716. Therapeutically, apolactoferrin supplements are used for immune support and infection prophylaxis, particularly in formula-fed infants. Emerging applications include adjunct therapy for inflammatory bowel disease and COVID-19, leveraging its cytokine-modulating and antiviral properties.

 

Source

Prepared from human milk shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

 

Storage

For long term, store Human Apolactoferrin at -20°C.

 

Applications

Iron Transport, Antimicrobial, Inflammation, Immunology.

 

Citations/Publications

NCBI: https://www.ncbi.nlm.nih.gov/protein/P02788

 

Shipped with ice packs

 

Gel Scan of Human Apolactoferrin

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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