Human Apolipoprotein AI (ApoA1)

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	Proteins Synonyms: ApoAI, ApoA1 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 10 mM NH4HCO3, pH 7.4 Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-120101-500UG 500 µg 185 € 16-16-120101-1MG 1 mg 310 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

ApoAI, ApoA1

 

Description of Human Apolipoprotein AI (ApoA1)

Human Apolipoprotein AI (ApoA1) is a 28 kDa protein. Apolipoprotein AI (Apo AI), constituting 75% of HDL-associated apolipoproteins, is a critical for reverse cholesterol transport (RCT), mediating cholesterol efflux from peripheral tissues to the liver. As the primary structural component of HDL, Apo AI stabilizes discoidal HDL particles, activates lecithin-cholesterol acyltransferase (LCAT) to esterify cholesterol, and facilitates HDL maturatioN. Its anti-inflammatory properties include blocking T-cell–monocyte interactions, reducing TNF-α and IL-1β production, and neutralizing oxidized LDL. Normal plasma levels range from 90–130 mg/100 mL, with concentrations inversely correlating with coronary heart disease (CHD) risk. Deficiencies in Apo AI underlie Tangier disease, characterized by near-absent HDL, cholesterol-laden macrophages, and premature atherosclerosis. Mutations like APOA1 p.Leu202Arg cause systemic amyloidosis, leading to cardiac and renal dysfunction. Reduced Apo AI levels also associate with insulin resistance, impaired β-cell function, and diabetes progression. Conversely, Apo AI overexpression enhances macrophage-specific RCT, attenuating atherosclerosis.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Apolipoprotein AI (ApoA1) at -80°C.

 

Applications

In Vitro Diagnostic, Cardiovascular Research, ALS, Diabetes.

 

Citations/Publications

Prathipati, P., et al., (2016), 'Development of novel HDL-mimicking α-tocopherol-coated nanoparticles to encapsulate nerve growth factor and evaluation of biodistribution', Polym. Chem., 7: pp 3897. Available at: DOI: 10.1039/c6py00616g
Tarlton, J. M. R., et al., (2021), 'Protection against Glucolipotoxicity by High Density Lipoprotein in Human PANC-1 Hybrid 1.1B4 Pancreatic Beta Cells: The Role of microRNA', Biology, 10: pp 218. Available at: https://doi.org/10.3390/biology10030218
Caridis, A. M., et al., (2019), 'Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells', Bioscience Reports (2019) 39(3): BSR20181155. Available at: https://doi.org/10.1042/BSR20181155
Scharadin, T. M., et al., (2017), 'Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system', PLoS ONE, 12(6): e0177761. Available at: https://doi.org/10.1371/journal.pone.0177761
Zheng, Y. Z., et al., (2017), 'Manipulating trypsin digestion conditions to accelerate proteolysis and simplify digestion workflows in development of protein mass spectrometric assays for the clinical laboratory', Clinical Mass Spectrometry, 6: pp 1–12. Available at: https://doi.org/10.1016/j.clinms.2017.10.001
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02647

 

Shipped with dry ice

 

Gel Scan of Human Apolipoprotein AI (ApoA1)

Fig. 1: SDS-PAGE Gel

 

 

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Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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