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Human Apolipoprotein AII
Delipidated whole molecule, immunogen grade
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Proteins Synonyms: ApoAII, ApoA2 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. Single band on polyacrylamide electrophoresis under reduced conditions. Physical State: Frozen in 10 mM NH4HCO3, pH 7.4 Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
ApoAII, ApoA2
Description of Human Apolipoprotein AII
Apolipoprotein A-II (ApoA-II), constituting 25% of HDL-associated apolipoproteins, circulates in plasma at 30–50 mg/100 mL. This 17.4 kDa protein stabilizes HDL structure and modulates lipid metabolism, though its physiological role remains debated. ApoA-II inhibits lecithin-cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP), influencing HDL remodeling and cholesterol efflux. While some studies suggest proatherogenic effects via reduced HDL antioxidant capacity, large prospective cohorts demonstrate an inverse correlation between ApoA-II levels and coronary artery disease (CAD) risk, independent of HDL cholesterol. Alcohol consumption increases ApoA-II production, correlating with elevated HDL-C and potential cardioprotection. Genetic variants like APOA2 rs5082 interact with saturated fat intake, modulating obesity and type 2 diabetes risk. Clinically, ApoA-II deficiency shows minimal lipid disruption, whereas elevated levels associate with hypertriglyceridemia, insulin resistance, and pancreatic cancer biomarker potential. Emerging therapies target ApoA-II’s role in amyloidosis inhibition and HDL particle engineering for atherosclerosis management. Despite conflicting mechanistic insights, ApoA-II remains a critical player in HDL dynamics and metabolic disease pathways.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Apolipoprotein AII at -80°C.
Applications
In Vitro Diagnostic, Cardiovascular Research.
Citations/Publications
Deng, M. et al., (2018), 'LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration', Nature, 562: pp 605–609. Available at: https://doi.org/10.1038/s41586-018-0615-z
Yamauchi, K., et al., (2020), 'The redox status of cysteine thiol residues of apolipoprotein E impacts on its lipid interactions', Biol. Chem., 401(5): pp 617–627. Available at: https://doi.org/10.1515/hsz-2019-0414
Negi, P., et al., (2016), 'Identification and analysis of anti-HDL scFv-antibodies obtained from phage display based synthetic antibody library', Clinical Biochemistry 49: pp 472–479. Available at: http://dx.doi.org/10.1016/j.clinbiochem.2015.11.020
Matsuura, H., et al., (2024), 'Apolipoprotein E isoforms and their Cys-thiol modifications impact LRP1-mediated metabolism of triglyceride-rich lipoproteins.', FEBS Lett, 598: pp 347-362. Available at: https://doi.org/10.1002/1873-3468.14803
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02652
Shipped with dry ice
Gel Scan of Human Apolipoprotein AII
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
