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Human Apolipoprotein B
Delipidated whole molecule
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Proteins Synonyms: ApoB, ApoB 100 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE; Single arc by IEP against whole human serum. Physical State: Lyophilized from 10 mM Na deoxycholate, pH 10.0, with 50 mM Na2CO3 and 50 mM NaCl. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
ApoB, ApoB 100
Description of Human Apolipoprotein B
Human Apolipoprotein B is a 550 kDa protein. Apolipoprotein B (Apo B), the principal structural protein of LDL, VLDL, and chylomicrons, exists in two isoforms: Apo B-100 (4536 amino acids, liver-derived) and Apo B-48 (2152 amino acids, intestinal). Apo B-100 mediates LDL receptor binding, enabling cellular cholesterol uptake, while Apo B-48 facilitates dietary fat absorption via chylomicrons. Both isoforms stabilize lipoprotein particles and coordinate lipid transport through interactions with microsomal triglyceride transfer protein (MTP). Elevated Apo B levels (>90 mg/100 mL) directly correlate with atherosclerotic cardiovascular disease (ASCVD) risk, outperforming LDL cholesterol as a predictor due to its one-to-one association with atherogenic particles. Mutations like APOB R3500Q cause familial hypercholesterolemia, impairing LDL receptor binding and increasing circulating LDL, leading to premature ASCVD. Apo B also contributes to insulin resistance and metabolic syndrome through pro-inflammatory pathways. Clinically, Apo B serves as a nonfasting biomarker for residual cardiovascular risk, guiding therapies like mipomersen, an antisense oligonucleotide that reduces Apo B synthesis and LDL levels in refractory hypercholesterolemia. Emerging applications include targeting Apo B in lipoprotein(a) reduction and hepatic steatosis management.
Source
Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Storage
For long term, store Human Apolipoprotein B at -20°C.
Applications
In Vitro Diagnostic, Cardiovascular Research, Diabetes Research.
Citations/Publications
Deng, M. et al., (2018), 'LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration', Nature, 562: pp 605–609. Available at: https://doi.org/10.1038/s41586-018-0615-z
Swearingen, C. A., et al., (2025), 'Measuring Lp(a) particles with a novel isoform-insensitive immunoassay illustrates efficacy of muvalaplin', J. Lipid Res., 66(1): pp 100723. Available at: https://doi.org/10.1016/j.jlr.2024.100723
Vogt, L. M., et al., (2020), 'Apolipoprotein E Triggers Complement Activation in Joint Synovial Fluid of Rheumatoid Arthritis Patients by Binding C1q', J Immunol., 204: pp 2779-2790. Available at: doi: 10.4049/jimmunol.1900372
NCBI: https://www.ncbi.nlm.nih.gov/protein/P04114
Shipped with ice packs
Gel Scan of Human Apolipoprotein B
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
