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Human Apolipoprotein B, Immunogen Grade
Delipidated whole molecule, Immunogen grade for antisera production
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Proteins Synonyms: ApoB, ApoB 100 Source: Human Plasma Purity: ≥ 98% by SDS-PAGE; Single arc by IEP against whole human serum. Physical State: Lyophilized from 10 mM Na deoxycholate, pH 10.0, with 50 mM Na2CO3 and 50 mM NaCl. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
ApoB, ApoB 100
Description of Human Apolipoprotein B, Immunogen Grade
Human Apolipoprotein B, Immunogen Grade is a 550 kDa protein. Apolipoprotein B (Apo B), the principal structural protein of LDL, VLDL, and chylomicrons, exists in two isoforms: Apo B-100 (4536 amino acids, liver-derived) and Apo B-48 (2152 amino acids, intestinal). Apo B-100 mediates LDL receptor binding, enabling cellular cholesterol uptake, while Apo B-48 facilitates dietary fat absorption via chylomicrons. Both isoforms stabilize lipoprotein particles and coordinate lipid transport through interactions with microsomal triglyceride transfer protein (MTP). Elevated Apo B levels (>90 mg/100 mL) directly correlate with atherosclerotic cardiovascular disease (ASCVD) risk, outperforming LDL cholesterol as a predictor due to its one-to-one association with atherogenic particles. Mutations like APOB R3500Q cause familial hypercholesterolemia, impairing LDL receptor binding and increasing circulating LDL, leading to premature ASCVD. Apo B also contributes to insulin resistance and metabolic syndrome through pro-inflammatory pathways. Clinically, Apo B serves as a nonfasting biomarker for residual cardiovascular risk, guiding therapies like mipomersen, an antisense oligonucleotide that reduces Apo B synthesis and LDL levels in refractory hypercholesterolemia. Emerging applications include targeting Apo B in lipoprotein(a) reduction and hepatic steatosis management.
Source
Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Storage
For long term, store Human Apolipoprotein B, Immunogen Grade at -20°C.
Applications
In Vitro Diagnostic, Cardiovascular Research, Diabetes Research, Antisera Production.
Citations/Publications
NCBI: https://www.ncbi.nlm.nih.gov/protein/P04114
Shipped with ice packs
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
