EN
Human Apolipoprotein CI
Delipidated whole molecule
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Proteins Synonyms: ApoCI, ApoC1 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 10 mM NH4HCO3, pH 7.4 Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
ApoCI, ApoC1
Description of Human Apolipoprotein CI
Human Apolipoprotein CI is a 6.6 kDa protein. Apolipoprotein CI (Apo CI) is a component of triglyceride-rich lipoproteins (VLDL, chylomicrons) and HDL, with normal plasma concentrations of 4–7 mg/100 mL. Synthesized primarily in the liver, Apo CI modulates lipid metabolism by inhibiting cholesteryl ester transfer protein (CETP) and lipoprotein lipase (LPL), while activating lecithin-cholesterol acyltransferase (LCAT). These interactions influence HDL remodeling and VLDL clearance, impacting systemic lipid homeostasis. Elevated Apo CI levels correlate with reduced visceral adiposity and protection against obesity and insulin resistance, likely through impaired lipid storage in adipose tissue. Conversely, the APOC1 H2 allele is linked to late-onset Alzheimer’s disease (LOAD), particularly in carriers of the APOE ε4 variant, by altering cerebral lipoprotein metabolism and amyloid-β clearance. In diabetes, glycation of Apo CI disrupts its CETP inhibitory function, exacerbating dyslipidemia and cardiovascular risk. Clinically, Apo CI serves as a biomarker for LOAD susceptibility and metabolic syndrome progression. Therapeutic strategies targeting its lipid-modulating properties or mitigating glycation effects hold promise for managing Alzheimer’s, diabetes, and obesity-related disorders.
Source
Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Storage
For long term, store Human Apolipoprotein CI at -20°C.
Applications
In Vitro Diagnostic, Cardiovascular, Diabetes, Alzheimer's, Obesity.
Citations/Publications
Deng, M. et al., (2018), 'LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration', Nature, 562: pp 605–609. Available at: https://doi.org/10.1038/s41586-018-0615-z
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02654/
Shipped with ice packs
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
