Human BMP-2 recombinant Protein

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Product Overview, Sizes and Prices



Synonyms: Bone morphogenetic protein 2, BDA2, BMP2A, bone morphogenetic protein 4, ZYME, BMP2B, OFC11, BMP2B1, MCOPS6.

Source: E. coli

Biological activity: ≤ 0.8g/ml

Purity: ≥ 95 % (SDS-PAGE, silver stained)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1195.950.005 5 g 75 €
1195.950.010 10 g 150 €
1195.950.050 50 g 350 €
1195.950.100 100 g 590 €
1195.950.250 250 g 990 €
1195.950.500 500 g 1.720 €
1195.950.199 1 mg 2.850 €

Please inquire for other vial sizes and custom vialing.



Product Details


Bone morphogenetic protein 2, BDA2, BMP2A, bone morphogenetic protein 4, ZYME, BMP2B, OFC11, BMP2B1, MCOPS6.


Description of Human BMP-2

Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains. BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease.


Biological Activity

The ED50 of 0.3-0.8g/ml was determined by its ability to induce alkaline phosphatase production by C2C12 myogenic cells. It corresponds to a specific activity of ≥ 0.125 U/mg.



We recommend a quick spin followed by reconstitution in 50mM acetic acid to a concentration of 0.1 mg/ml. It is also be soluble in most aqueous buffers when the pH is below 6.0. Do not vortex. This solution can be stored at 2-8C for up to 1 week or in working aliquots at -20C to -80C. Working aliquots should be at the highest possible concentration.



The lyophilized protein is stable at room temperature for up 1 month and at least until the lot specific expiry date if kept below -18C. Reconstituted BMP-2 is stable for at least 12 months when stored in working aliquots at -20C to -80C. Please avoid repeated freeze-thaw cycles.


Lupe Zoom

Amino Acid Sequence



Shipping symbol Shipped at room temperature









To buy Human BMP-2 (W1195950005, W1195950010, W1195950050, W1195950100, W1195950250, W1195950500, W1195950199) please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button Shopping List & Order Form or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human BMP-2 is an alternative for the no longer available Promokine BMP-2, human, recombinant (E. coli) (C-67310).


All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.


Errors, changes and availability excepted.




Payment Methods

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Free shipping for orders above 500 € within Germany

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