Human BMP-2 recombinant Protein

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Phone: +49 (0) 40 . 43 20 84 48 0

E-Mail: info@active-bioscience.de

 

Product Overview, Sizes and Prices

 

Protein

Synonyms: Bone morphogenetic protein 2, BDA2, BMP2A, bone morphogenetic protein 4, ZYME, BMP2B, OFC11, BMP2B1, MCOPS6

Source: E. coli

Biological activity: ≤ 0.8g/ml

Purity: ≥ 95 % (SDS-PAGE, silver stained)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1195.950.005 5 g 75 €
1195.950.010 10 g 150 €
1195.950.050 50 g 350 €
1195.950.100 100 g 590 €
1195.950.250 250 g 990 €
1195.950.500 500 g 1.720 €
1195.950.199 1 mg 2.850 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

Bone morphogenetic protein 2, BDA2, BMP2A, bone morphogenetic protein 4, ZYME, BMP2B, OFC11, BMP2B1, MCOPS6

 

Description of Human BMP-2

Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains. BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease.

 

Biological Activity

The ED50 of 0.3-0.8g/ml was determined by its ability to induce alkaline phosphatase production by C2C12 myogenic cells. It corresponds to a specific activity of ≥ 0.125 U/mg.

 

Reconstitution

We recommend a quick spin followed by reconstitution in 50mM acetic acid to a concentration of 0.1 mg/ml. It is also be soluble in most aqueous buffers when the pH is below 6.0. Do not vortex. This solution can be stored at 2-8C for up to 1 week or in working aliquots at -20C to -80C. Working aliquots should be at the highest possible concentration.

 

Stability

The lyophilized protein is stable at room temperature for up 1 month and at least until the lot specific expiry date if kept below -18C. Reconstituted BMP-2 is stable for at least 12 months when stored in working aliquots at -20C to -80C. Please avoid repeated freeze thaw cycles.

 

Amino Acid Sequence

MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR

 

 

 

To buy Human BMP-2 please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button Shopping List & Order Form to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

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Errors, changes and availability excepted.

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500  within Germany

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