Human BMP-2 recombinant Protein

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Product Overview, Sizes and Prices



Synonyms: Bone morphogenetic protein 2, BDA2, BMP2A, bone morphogenetic protein 4, ZYME, BMP2B, OFC11, BMP2B1, MCOPS6

Source: E. coli

Biological activity: ≤ 0.8g/ml

Purity: ≥ 95 % (SDS-PAGE, silver stained)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1195.950.005 5 g 75 €
1195.950.010 10 g 150 €
1195.950.050 50 g 350 €
1195.950.100 100 g 590 €
1195.950.250 250 g 990 €
1195.950.500 500 g 1.720 €
1195.950.199 1 mg 2.850 €

Please inquire for other vial sizes and custom vialing.



Product Details


Bone morphogenetic protein 2, BDA2, BMP2A, bone morphogenetic protein 4, ZYME, BMP2B, OFC11, BMP2B1, MCOPS6


Description of Human BMP-2

Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains. BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease.


Biological Activity

The ED50 of 0.3-0.8g/ml was determined by its ability to induce alkaline phosphatase production by C2C12 myogenic cells. It corresponds to a specific activity of ≥ 0.125 U/mg.



We recommend a quick spin followed by reconstitution in 50mM acetic acid to a concentration of 0.1 mg/ml. It is also be soluble in most aqueous buffers when the pH is below 6.0. Do not vortex. This solution can be stored at 2-8C for up to 1 week or in working aliquots at -20C to -80C. Working aliquots should be at the highest possible concentration.



The lyophilized protein is stable at room temperature for up 1 month and at least until the lot specific expiry date if kept below -18C. Reconstituted BMP-2 is stable for at least 12 months when stored in working aliquots at -20C to -80C. Please avoid repeated freeze thaw cycles.


Amino Acid Sequence





Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.



To buy Human BMP-2 (W1195950005, W1195950010, W1195950050, W1195950100, W1195950250, W1195950500, W1195950199) please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button Shopping List & Order Form to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.


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