Human C-Reactive Protein (CRP)

1. Home
2. Proteins
3. Human Proteins

Product Overview, Sizes and Prices
	Proteins Synonyms: CRP Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 20mM Tris, pH 8.0, with 280 mM NaCl, 5mM CaCl2, and 0.05% NaN3 Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-031816-100UG 100 µg 55 € 16-16-031816-1MG 1 mg 165 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

CRP

 

Description of Human C-Reactive Protein (CRP)

C-reactive protein (CRP), an acute-phase reactant, belongs to the pentraxin family characterized by calcium-dependent ligand binding. Each 24 kDa subunit contains a phosphocholine (PC)-binding site on its recognition face, enabling opsonization of pathogens and apoptotic cells via exposed PC moieties on bacterial membranes or oxidized low-density lipoprotein (OxLDL). CRP activates the classical complement pathway by binding C1q and Fcγ receptors, enhancing phagocytosis and inflammatory cytokine release. Under inflammatory conditions, pentameric CRP (pCRP) dissociates into pro-inflammatory monomers (mCRP) at sites of endothelial activation, amplifying leukocyte adhesion and vascular permeability. Clinically, CRP serves as a biomarker for systemic inflammation, with plasma levels rising from <5 mg/L in healthy individuals to >200 mg/L in severe sepsis or trauma. Elevated baseline high-sensitivity CRP (hs-CRP >3 mg/L) predicts cardiovascular events, correlating with atherosclerosis progression and endothelial dysfunction. In oncology, CRP >10 mg/dL portends poor prognosis in pancreatic cancer, reflecting tumor-associated inflammation. CRP also links metabolic dysregulation, with levels >2.9 mg/L increasing type 2 diabetes risk via IL-6-mediated insulin resistance6. Autoimmune disorders like rheumatoid arthritis show CRP elevation proportional to disease activity, while Alzheimer’s disease involves CRP binding amyloid-β plaques to modulate neuroinflammation.

 

Source

Plasma shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

 

Storage

For long term, store Human C-Reactive Protein (CRP) at ≤ -80°C.

 

Applications

In Vitro Diagnostics, Inflammation, Complement System, Cardiovascular Disease, Rheumatoid Arthritis, Cancer, Alzheimer's.

 

Citations/Publications

NCBI: https://www.ncbi.nlm.nih.gov/protein/P02741

 

Shipped with dry ice

 

Gel Scan of Human C-Reactive Protein (CRP)

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

To buy Human C-Reactive Protein (CRP) please click on the Shopping List Symbol right from the indicated price. This will add Human C-Reactive Protein (CRP) to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

 

For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.