Human Catalase

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	Proteins Synonyms: H2O2:H2O2 oxidoreductase, Catalase-peroxidase, CAT Biological Activity: > 50, 000 units/mg protein Source: Human Blood Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 50 mM Tris-HCl, pH 8.0. Manufacturer:  Athens Research & Technology	Article No. Size Price   16-05-030000-500UG 500 µg 185 € 16-05-030000-1MG 1 mg 315 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

H₂O2:H₂O2 oxidoreductase, Catalase-peroxidase, CAT

 

Description of Human Catalase

Human Catalase is a 230 kDa protein. Human catalase is a tetrameric enzyme composed of four identical subunits, each containing a heme group coordinated by tyrosine at the active site. This iron-dependent oxidoreductase catalyzes the rapid decomposition of hydrogen peroxide (2H₂O2→2H₂O+O2). Beyond its primary antioxidant role, catalase works with superoxide dismutase and glutathione peroxidase to neutralize reactive oxygen species (ROS), protecting cellular components from oxidative damage. Genetic mutations in the CAT gene cause acatalasemia, characterized by severe catalase deficiency (<10% activity) linked to oral ulcerations, gangrene, and heightened susceptibility to type 2 diabetes due to pancreatic β-cell damage. Polymorphisms in catalase (e.g., -262 C/T promoter variant) correlate with oxidative stress-related pathologies, including hypertension, Alzheimer's disease, and vitiligo. Elevated catalase activity occurs in atherosclerosis and certain cancers as a compensatory response to chronic oxidative stress. Therapeutically, catalase is explored for treating ischemia-reperfusion injury through gene therapy and nanoparticle delivery systems. Recent clinical trials investigate catalase mimetics and combination antioxidant therapies for neurodegenerative disorders, leveraging its neuroprotective effects against amyloid-β toxicity.

 

Source

Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests

 

Biological Activity

> 50, 000 units/mg protein. One unit is equal to the amount of enzyme that will decompose 1 µmol of hydrogen peroxide per minute at 25°C, pH 7.0.

 

Storage

For long term, store Human Catalase at ≤ -80°C.

 

Applications

Cell Culture Media, Protein Chemistry Studies, Enzymatic Activity Assays.

 

Citations/Publications

Yang, T., et al. (2018) 'Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation', J Immunol, 201: pp.1389-1399. Available at: doi: 10.4049/jimmunol.1800324 
Srauss, S., et al. (2018) 'Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging', Nature Methods, 15: pp. 685-688. Available at: https://doi.org/10.1038/s41592-018-0105-0
Woodall, B. P., et al. (2019) 'Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice', JCI Insight., 4(10): e127713. Available at: https://doi.org/10.1172/jci.insight.127713
NCBI: https://www.ncbi.nlm.nih.gov/protein/P04040

 

Shipped with dry ice

 

Gel Scan of Human Catalase

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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