Human Cathepsin D

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Product Overview, Sizes and Prices
	Proteins Synonyms: CatD, CTSD, CPSD Biological Activity: ≥ 300 units per mg protein Source: Human Liver Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 2 mM Na phosphate, pH 6.5. Manufacturer:  Athens Research & Technology	Article No. Size Price   16-12-030104-25UG 25 µg 280 € 16-12-030104-50UG 50 µg 395 € 16-12-030104-100UG 100 µg 660 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

CatD, CTSD, CPSD

 

Description of Human Cathepsin D

Human Cathepsin D is a 42 kDa protein. Cathepsin D (CatD), a lysosomal aspartyl protease encoded by the CTSD gene, functions in protein degradation and activation of bioactive precursors through cleavage at acidic pH. Its structure includes a signal peptide, propeptide, and catalytic domain with two aspartic residues essential for enzymatic activity. Estrogen receptor (ER) signaling drives CatD overexpression in hormone-responsive breast cancers via TATA-dependent transcription initiation, mediated by upstream stimulatory factors USF-1/USF-2 binding to E-box elements. In ER-positive tumors, CatD secretion promotes metastasis by degrading extracellular matrix components and enhancing cell motility. Clinically, CatD expression correlates with aggressive breast cancer phenotypes, including high histological grade, and reduced survival. In Alzheimer’s disease (AD), CatD colocalizes with amyloid-β (Aβ) plaques and neurofibrillary tangles, where it degrades both Aβ42 and tau under normal conditions. However, Aβ42 accumulation competitively inhibits CatD, impairing tau clearance and exacerbating neurodegeneration. Cigarette smoke elevates CatD activity in alveolar macrophages and bronchoalveolar lavage fluid, contributing to emphysema via lung matrix degradation. Therapeutically, CatD serves as a prognostic biomarker for breast cancer stratification and a predictor of tamoxifen resistance. Inhibitors like pepstatin A and small-molecule analogs targeting its active site are under investigation for metastatic breast cancer and AD3. In smokers, monitoring BALF CatD levels (>3, 600 U/mL) may identify early lung damage, guiding preventive interventions. These dual roles in proteostasis and disease underscore CatD’s potential as a multifunctional therapeutic node.

 

Source

Prepared from liver shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

 

Biological Activity

≥ 300 units per mg protein. One unit is defined as the amount of enzyme that digests hemoglobin-releasing peptides, which are soluble in 10% TCA. The reaction is measured by an increase in A280 of 1.0 per 60 minutes at 37 °C.

 

Storage

For long term, store Human Cathepsin D at ≤ -20°C.

 

Applications

Cancer, Alzheimer's, In Vitro Diagnostic.

 

Citations/Publications

Kryštůfek, R., et al., (2021), 'Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery', J. Med. Chem., 64: pp 6706−6719. Available at: https://doi.org/10.1021/acs.jmedchem.0c02177
Lambeth, T. R., et al., (2021), 'Proteolysis of Amyloid β by Lysosomal Enzymes as a Function of Fibril Morphology', ACS Omega, 6: pp 31520−31527. Available at:https://doi.org/10.1021/acsomega.1c03915
NCBI: https://www.ncbi.nlm.nih.gov/protein/P07339

 

Shipped with ice packs

 

Gel Scan of Human Cathepsin D

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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