Human Cathepsin G

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	Proteins Synonyms: CatG, CTSG Biological Activity: 2-4 units/mg protein Source: Human Neutrophils Purity: ≥ 95% by SDS-PAGE Physical State: Salt-free lyophilized solid. Manufacturer:  Athens Research & Technology	Article No. Size Price   16-14-030107-50UG 50 µg 225 € 16-14-030107-100UG 100 µg 375 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

CatG, CTSG

 

Description of Human Cathepsin G

Human Cathepsin G is a 23.5 kDa protein. Cathepsin G (CTSG), encoded by the CTSG gene on chromosome 14q11.2, is a neutrophil-derived serine protease stored in azurophilic granules. Structurally, it features a catalytic triad (His57, Asp102, Ser195) that enables dual chymotryptic and tryptic activities in humans due to a primate-specific Glu226 substitution. Beyond degrading collagen and proteoglycans, CTSG processes chemokines (e.g., CCL15, CXCL5) into potent chemoattractants, activates matrix metalloproteinases (MMP-2, MMP-9) to drive tissue remodeling, and generates angiotensin II from angiotensinogen via cleavage at Phe8 and Tyr4. This angiotensin II production enhances vascular permeability by disrupting endothelial cadherins and tight junctions, contributing to edema in sepsis and acute lung injury1. Clinically, CTSG is implicated in emphysema through synergistic elastin degradation with neutrophil elastase and proteinase 3, and in rheumatoid arthritis (RA) by recruiting monocytes via chemerin activation and exacerbating synovial inflammation. Elevated CTSG levels correlate with RA severity and serve as a diagnostic biomarker. In cystic fibrosis, dysregulated CTSG promotes lung matrix breakdown, while in Alzheimer’s disease, it cleaves amyloid-β precursors. Therapeutically, CTSG inhibitors like α1-antichymotrypsin and investigational monoclonal antibodies attenuate vascular leakage and inflammation in preclinical models. Its dual protease activities and role in immune cell recruitment position CTSG as a promising target for autoimmune and degenerative disorders.

 

Source

Neutrophils shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

 

Biological Activity

2-4 units/mg protein. One unit is defined as the amount of enzyme that hydrolyzes 1 µmol of Suc-Ala-Ala Pro-Phe-pNA (1 mM) per minute at 25 °C in 160 mM Tris-HCl, pH 7.4, with 1.6 M NaCl.

 

Storage

For long term, store Human Cathepsin G at ≤ -20°C.

 

Applications

Sepsis, Emphysema, Rheumatoid Arthritis, Inflammation, Cystic Fbrosis, In Vitro Diagnostic.

 

Citations/Publications

Nielsen, N. S., et al., (2022), 'Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family', NATURE COMMUNICATIONS., 13: pp.3033. Available at: https://doi.org/10.1038/s41467-022-30758-x
Li, Y., et al. (2024), 'Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region', Nature Communications, 15: pp. 4359. Available at: https://doi.org/10.1038/s41467-024-48655-w
Kim, T. K., et al., (2020), 'Amblyomma americanum serpin 41 (AAS41) inhibits inflammation by targeting chymase and chymotrypsin', International Journal of Biological Macromolecules, 156: pp 1007–1021. Available at: https://doi.org/10.1016/j.ijbiomac.2020.04.088
Leborgne, N. G. F., et al., (2024), Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation', JCI Insight., 9(7) : pp e174133. Available at: https://doi.org/10.1172/jci.insight.174133
Rodriguez-Rios, M., et al., (2024), 'A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages', COMMUNICATIONS CHEMISTRY, 6: pp 237. Available at: https://doi.org/10.1038/s42004-023-01035-9
NCBI: https://www.ncbi.nlm.nih.gov/protein/P08311/

 

Shipped with ice packs

 

Gel Scan of Human Cathepsin G

Fig. 1: SDS-PAGE Gel

 

 

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Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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