EN
Human Complement C3c
Native, fragment of whole molecule Complement C3
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Proteins Synonyms: C3c Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. Reacts to C3 antisera on Western Blot Negative against C4 antisera on Western Blot Physical State: Frozen in PBS, pH 7.4 Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
C3c
Description of Human Complement C3c
Complement C3c is a stable proteolytic fragment derived from complement component 3 (C3), the most abundant protein in the complement system (~1.2–1.5 mg/mL in plasma). C3 exists as a heterodimer comprising α (115 kDa) and β (75 kDa) chains linked by disulfide bonds. Activation via classical, lectin, or alternative pathways cleaves C3 into C3a (anaphylatoxin) and C3b (opsonin), with C3b further processed by Factor I into iC3b and finally C3c (140 kDa) and C3d. Unlike transient C3b, C3c lacks covalent binding capacity, making it a soluble biomarker of complement activation. C3c quantification in plasma serves as a stable indicator of complement activation in conditions like sepsis and autoimmune diseases. Clinically, C3c assays aid in monitoring lupus and post-transplant rejection. Therapeutic C3 inhibitors (e.g., pegcetacoplan) target C3 cleavage to treat paroxysmal nocturnal hemoglobinuria and geographic atrophy, demonstrating broader potential in C3 glomerulopathy and age-related macular degeneration. Additionally, C3c’s role in immune complex clearance informs drug development for autoimmune and inflammatory disorders.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Complement C3c at ≤ -80°C.
Applications
Glomerulopathy, Kidney Disease, Lupus Nephritis, Infection, Sepsis, Inflammation, In Vitro Diagnostic.
Citations/Publications
Miyamoto, S., et al., (2018), 'Multiple Reaction Monitoring for the Quantitation of Serum Protein Glycosylation Profiles: Application to Ovarian Cancer', J. Proteome Res., 17: pp 222−233. Available at: DOI: 10.1021/acs.jproteome.7b00541
Ajamian, M., et al., (2019), 'Serum zonulin as a marker of intestinal mucosal barrier function: May not be what it seems', PLoS ONE 14(1): e0210728. Available at: https://doi.org/10.1371/journal.pone.0210728
Shipped with dry ice
Gel Scan of Human Complement C3c
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
