Human Complement C5

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Product Overview, Sizes and Prices
	Proteins C5 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. Reacts to C5 antisera on Western Blot Physical State: Frozen in PBS, pH 7.4 Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-030305-50UG 50 µg 185 € 16-16-030305-250UG 250 µg 480 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

C5

 

Description of Human Complement C5

Complement C5, a glycoprotein composed of α (115 kDa) and β (75 kDa) chains, serves as the linchpin of complement-mediated immunity. Cleaved by C5 convertases into C5a (potent anaphylatoxin) and C5b (initiator of membrane attack complex/MAC), it bridges inflammatory signaling and pathogen lysis. C5a drives chemotaxis, leukocyte activation, and vascular permeability via C5aR1/C5aR2 receptors, while C5b-9 (MAC) induces microbial cytolysis. C5 deficiency increases susceptibility to recurrent pyogenic infections (e.g., Neisseria) and Leiner’s disease. Elevated C5a correlates with rheumatoid arthritis, Guillain-Barré syndrome, and chemotherapy-induced neuropathy.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Complement C5 at ≤ -80°C.

 

Applications

Inflammation, Infection, Autoimmune Diseases, Myasthenia Gravis, Age Related Macular Degeneration.

 

Citations/Publications

NCBI: https://www.ncbi.nlm.nih.gov/protein/P01031/

 

Shipped with dry ice

 

Gel Scan of Human Complement C5

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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