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Human CYR61 recombinant Protein
Human CYR61, recombinant
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Proteins Synonyms: CCN1, GIG1 protein, IGF-binding protein 10. Source: E. coli Biological Activity: ≥ 500 units/mg Purity: ≥ 95 % (SDS-PAGE, HPLC) Physical State: Lyophilized Manufacturer: |
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Active Bioscience
Produktdetails
Synonyms
CCN1, GIG1 protein, IGF-binding protein 10.
Description of Human CYR61
Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK). CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers.
Biological Activity
The ED50 of ≤ 2.0 µg/ml was determined by the dose-dependent stimulation of the proliferation of murine 3T3 cells. It corresponds to a specific activity of ≥ 500 u/mg.
Reconstitution
We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.
Stability
The lyophilized protein is stable at room temperature for up to 3 weeks and at least until the lot specific expiry date if kept below -18°C. Reconstituted CYR61 should be stored in working aliquots at -20°C to -80°C. Please avoid repeated freeze thaw cycles.
Amino Acid Sequence
TCPAACHCPL EAPKCAPGVG LVRDGCGCCK VCAKQLNEDC SKTQPCDHTK GLECNFGASS TALKGICRAQ SEGRPCEYNS RIYQNGESFQ PNCKHQCTCI DGAVGCIPLC PQELSLPNLG CPNPRLVKVT GQCCEEWVCD EDSIKDPMED QDGLLGKELG FDASEVELTR NNELIAVGKG SSLKRLPVFG MEPRILYNPL QGQKCIVQTT SWSQCSKTCG TGISTRVTND NPECRLVKET RICEVRPCGQ PVYSSLKKGK KCSKTKKSPE PVRFTYAGCL SVKKYRPKYC GSCVDGRCCT PQLTRTVKMR FRCEDGETFS KNVMMIQSCK CNYNCPHANE AAFPFYRLFN DIHKFRD
Shipped at room temperature
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
