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Human Defensins, Alpha
Mixture of native whole molecule defensins from Neutrophils
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Proteins Synonyms: Human Neutrophil Peptides, HNP Source: Human Neutrophils Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 1 M acetic acid. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
Human Neutrophil Peptides, HNP
Description of Human Defensins, Alpha
Alpha-defensins are small (3-4 kDa), cysteine-rich cationic peptides characterized by a conserved triple β-sheet structure stabilized by three disulfide bonds. Primarily secreted by neutrophils and Paneth cells, these peptides exhibit broad-spectrum antimicrobial activity against bacteria, fungi, and enveloped viruses via membrane disruption. Their cationic nature facilitates electrostatic attraction to negatively charged microbial membranes, forming voltage-dependent pores that induce osmotic lysis. Beyond direct pathogen killing, alpha-defensins (e.g., HNP1-3) promote neutrophil extracellular trap (NET) formation and modulate immune responses by enhancing phagocytosis, regulating cytokine production, and suppressing glucocorticoid-mediated immunosuppression. Elevated alpha-defensin levels correlate with alcohol-related liver cirrhosis severity, where they predict hepatic encephalopathy and mortality. In prosthetic joint infections (PJI), synovial alpha-defensin detection via lateral flow assays achieves 92-100% specificity, serving as a rapid diagnostic biomarker. Genetic polymorphisms link alpha-defensin dysregulation to autoimmune disorders like lupus and neuropsychiatric conditions such as schizophrenia. Conversely, deficiencies increase susceptibility to pyogenic infections, particularly in immunocompromised individuals.
Source
Neutrophils shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Storage
For long term, store Human Defensins, Alpha at ≤ -80°C.
Applications
In Vitro Diagnostic, Antimicrobials, NETosis, Cirrhosis, Autoimmune Disease,.
Citations/Publications
Bickman, A. V., et al., (2020), '3D Printed Microfluidic Devices for Solid-Phase Extraction and On- Chip Fluorescent Labeling of Preterm Birth Risk Biomarkers', Anal. Chem., 92: pp 12322−12329. Available at: https://dx.doi.org/10.1021/acs.analchem.0c01970
Maeda, T., et al., (2016), 'Low concentrations of human neutrophil peptide ameliorate experimental murine colitis', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 38: pp 1777-1785. Available at: DOI: 10.3892/ijmm.2016.2795
Shipped with dry ice
Gel Scan of Human Defensins, Alpha
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
