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Human Erythropoietin, EPO-a-Fc (glycosylated, CHO) recombinant Protein
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Proteins Synonyms: EPO-a, EPO-alpha, Epoetin, EP, MGC138142. Source: CHO Biological Activity: ≥ 5 x 105 IU/mg Purity: ≥ 98 % (SDS-PAGE, RP-HPLC) Physical State: Lyophilized Manufacturer: |
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Active Bioscience
Produktdetails
Synonyms
EPO-a, EPO-alpha, Epoetin, EP, MGC138142.
Description of Human Erythropoietin, EPO-a-Fc (glycosylated, CHO)
Erythropoietin-alpha Fc-Chimera Human Recombinant is produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology is a dimeric, glycosilated, polypeptide chain consisting of two mature human EPO molecules linked to the Fc portion of human IgG1. The Fc component contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. As a result of glycosylation, the recombinant protein migrates with an apparent molecular mass of 140 kDa in non-reducing SDS-PAGE.
Biological Activity
The ED50 as determined by the dose-dependent stimulation of human megakaryoblastic leukemia cells is less than 2.0 ng/ml, corresponding to a Specific Activity of 5.0 x 105 IU/mg.
Reconstitution
We recommend a quick spin followed by reconstitution in sterile water to a concentration of at least 100 µg/ml, which can then be further diluted to other aqueous solutions. Do not vortex.
Stability
Lyophilized Erythropoietin-a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution EPO-alpha should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA, order number: 2835.955.xyz or 2835.958.xyz, or BSA, order number: 2835.919.xyz). Please avoid repeated freeze-thaw cycles.
Shipped at room temperature
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
