Human Fetuin-A/AHSG (glycosylated, HEK) recombinant Protein

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Phone: +49 (0) 40 . 43 20 84 48 0

E-Mail: info@active-bioscience.de

 

Product Overview, Sizes and Prices

 

Protein

Synonyms: Alpha-2-HS-glycoprotein, Fetuin-A, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, AHSG, FETUA, AHS, A2HS, HSGA, PRO2743.

Source: HEK

Purity: ≥ 98 % (SDS-PAGE, RP-HPLC)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
3060.955.010 10 µg on request
3060.955.050 50 µg on request

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

Alpha-2-HS-glycoprotein, Fetuin-A, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, AHSG, FETUA, AHS, A2HS, HSGA, PRO2743.

 

Description of Human Fetuin-A/AHSG (glycosylated, HEK)

Recombinant human Fetuin A produced in HEK cells is a glycosylated heterodimeric protein of 309 amino acids (A-chain with 282 aa; B-chain with 27 aa). It has a molecular mass of 32,9 kDa, but due to glycosylation migrates at 45-55 kDa in SDS-Page under non-reducing conditions. Fetuin A is a human plasma glycoprotein belonging to the Cystatin family of protease inhibitors. It is highly expressed in embryonic cells and adult hepatocytes and is expressed to a lesser extent in monocytes/macrophages. Fetuin A is a major serum protein component that exerts various calcium-dependent physiological activities and can mediate growth signaling in certain tumor cells. It also can act as a natural antagonist against specific TGF-ß and BMP signaling proteins.

 

Biological Activity

The IC50 of ≤ 100nM was determined by its ability to inhibit Cathespin V cleavage of a fluorogenic peptide substrate Z-LR-AMC (RLUs).

 

Reconstitution

We recommend a quick spin followed by reconstitution in sterile Water at a concentration of 0.1 mg/ml, which can then be further diluted into other aqueous or buffered solutions.

 

Stability

The lyophilized protein is stable for at least 1 year from date of receipt if stored at -20°C to -80°C. Reconstituted Fetuin A should be stored at 4°C if entire vial will be used within 1-2 weeks. It is stable for least 3 months when stored in working aliquots with a carrier protein at -20°C. Please avoid repeated freeze-thaw cycles.

 

Amino Acid Sequence

A-Chain: APHGPGLIYR QPNCDDPETE EAALVAIDYI NQNLPWGYKH TLNQIDEVKV WPQQPSGELF EIEIDTLETT CHVLDPTPVA RCSVRQLKEH AVEGDCDFQL LKLDGKFSVV YAKCDSSPDS AEDVRKVCQD CPLLAPLNDT RVVHAAKAAL AAFNAQNNGS NFQLEEISRA QLVPLPPSTY VEFTVSGTDC VAKEATEAAK CNLLAEKQYG FCKATLSEKL GGAEVAVTCT VFQTQPVTSQ PQPEGANEAV PTPVVDPDAP PSPPLGAPGL PPAGSPPDSH VL

B-Chain: TVVQPSVG AAAGPVVPPC PGRIRHFKV

 

 

 

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Errors, changes and availability excepted.

 

 

Payment Methods

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Shipping

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