Human FGF-5 recombinant Protein
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Fibroblast Growth Factor 5, Heparin-Binding Growth Factor 5, HBGF-5, Smag-82, TCMGLY
Description of Human FGF-5
Recombinant Human FGF-5 is a 252 amino acid protein, with a molecular mass of 27,7 kDa. Fibroblast Growth Factor-5 (FGF-5) is a secreted, heparin-binding growth factor belonging to the fibroblast growth factor (FGF) family. FGF family members possess extensive mitogenic and cell survival functions, and are involved in various biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-5 binds to FGFR 1c and 2c, and plays a regulatory role in the hair growth cycle. In vitro, human FGF-5 is a mitogen for Balb/3T3 fibroblasts and bovine heart endothelial cells. FGF5 is also a major muscle-derived survival factor for cultured spinal motoneurons. Developmentally, FGF5 mRNA is originally found in the embryoblast followed by the lateral somatic mesoderm, where it may play a part in angiogenesis, as well as the myotomes cranial to the tail region, where it may delay terminal myoblast differentiation during cell migration.
The ED50 of ≤ 0.5 ng/ml was determined by the dose-dependent stimulation of thymidin uptake of BaF3 cells expressing FGF-receptors. It corresponds to a specific activity of ≥ 2.0 x 106 units/mg.
We recommend a quick spin followed by reconstitution in water to a concentration of at least 100 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week or in working aliquots at -20°C to -80°C. Working aliquots should be at the highest practical concentration. For long term storage we recommend to add at least 0.1% HSA (order number: 2835.955.xyz or 2835.958.xyz) or BSA.
The lyophilized protein is stable at room temperature for up to 1 month and at least until the lot specific expiry date if kept below -18°C. Reconstituted FGF-6 should be stored in working aliquots at -20°C to -80°C if possible with carrier protein. Please avoid repeated freeze thaw cycles.
Amino Acid Sequence
MAWAHGEKRL APKGQPGPAA TDRNPRGSSS RQSSSSAMSS SSASSSPAAS LGSQGSGLEQ SSFQWSPSGR RTGSLYCRVG IGFHLQIYPD GKVNGSHEAN MLSVLEIFAV SQGIVGIRGV FSNKFLAMSK KGKLHASAKF TDDCKFRERF QENSYNTYAS AIHRTEKTGR EWYVALNKRG KAKRGCSPRV KPQHISTHFL PRFKQSEQPE LSFTVTVPEK KKPPSPIKSK IPLSAPRKNT NSVKYRLKFR FG
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