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Human GC Globulin
Mixture of Native whole molecule from multiple donor pool
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Proteins Synonyms: GC, DBP, DBP/GRD3, HEL-S-51, VDBG, VDBP, Gc-MAF, GcMAF, vitamin D binding protein, DBP-maf, VDB, GC vitamin D binding protein, Group Specific Component Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 20 mM Na phosphate, pH 7.4, with 150 mM NaCl. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
GC, DBP, DBP/GRD3, HEL-S-51, VDBG, VDBP, Gc-MAF, GcMAF, vitamin D binding protein, DBP-maf, VDB, GC vitamin D binding protein, Group Specific Component
Description of Human GC Globulin
Human GC Globulin is a 56 kDa protein. Vitamin D-binding protein (DBP/GC-globulin) serves as the primary transporter of vitamin D metabolites (25OHD, 1, 25(OH)2D) in plasma, maintaining their solubility and bioavailability. Structurally, DBP comprises three domains, with domain I harboring a high-affinity binding site for vitamin D metabolites. Beyond sterol transport, DBP binds monomeric actin with nanomolar affinity, preventing pathological actin polymerization in circulation-a critical function during tissue injury. It also interacts with immune cells, binding to surface receptors on B and T lymphocytes to modulate chemotaxis and inflammatory responses. Reduced DBP levels correlate with severe liver diseases such as cirrhosis and acute-on-chronic liver failure, where impaired synthesis exacerbates vitamin D deficiency and actin scavenging dysfunction. In Itai-Itai disease, DBP loss in urine disrupts vitamin D transport, contributing to cadmium-induced osteomalacia7. Genetic polymorphisms (e.g., Gc1F, Gc1S, Gc2) influence DBP’s binding affinity, linking specific alleles to viral infection susceptibility and autoimmune disorders like lupus. Low DBP levels also associate with non-alcoholic fatty liver disease (NAFLD) progression and type 2 diabetes, where pancreatic α-cell dysfunction arises from disrupted actin cytoskeleton regulation.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human GC Globulin at ≤ -20°C.
Applications
Glycobiology, Vitamin D Metabolism, Inflammation, Liver Damage/Disease, Itai-Itai Disease, Autoimmune Disease, Diabetes, In Vitro Diagnostic.
Citations/Publications
Chapron, B. D., et al., (2018), 'Reevaluating the Role of Megalin in Renal Vitamin D Homeostasis Using a Human Cell-Derived Microphysiological System', ALTEX 35(4): pp 504-515. Available at: doi:10.14573/altex.1803161
Lidberg, K. A., et al., (2024), 'Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system', npj Microgravity 10: 75. Available at: https://doi.org/10.1038/s41526-024-00415-2
Gliozzi, M. L., et al., (2019), 'Hemoglobin alters vitamin carrier uptake and vitamin D metabolism in proximal tubule cells: implications for sickle cell disease', Am J Physiol Cell Physiol 317: pp C993–C1000. Available at: doi:10.1152/ajpcell.00287.2019
Kanie, Y., et al., (2023), 'Investigation of the Protective Effect for GcMAF by a Glycosidase Inhibitor and the Glycan Structure of Gc Protein', Molecules, 28: pp 1570. Available at: https://doi.org/10.3390/molecules28041570
Borges, C. R., et al., (2016), 'Glycan structure of Gc Protein-derived Macrophage Activating Factor as revealed by mass spectrometry', Archives of Biochemistry and Biophysics 606: pp 1e13. Available at: http://dx.doi.org/10.1016/j.abb.2016.08.006
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02774/
Shipped with ice packs
Gel Scan of Human GC Globulin
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
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