Human GDF-15 / MIC-1 recombinant Protein

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Product Overview, Sizes and Prices

 

Protein

Synonyms: Macrophage inhibitory cytokine 1, Placental TGF-beta, MIC 1, NAG-1, PLAB, PTGFB, Placental bone morphogenetic protein, Prostate differentiation factor, PDF, NSAID-activated gene 1 protein, GDF15, MIC1.

Source: E. coli

Biological activity: See below

Purity: ≥ 95 % (SDS-PAGE)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1437.950.005 5 g 60 €
1437.950.020 20 g 159 €
1437.950.199 1 mg 3.190 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

Macrophage inhibitory cytokine 1, Placental TGF-beta, MIC 1, NAG-1, PLAB, PTGFB, Placental bone morphogenetic protein, Prostate differentiation factor, PDF, NSAID-activated gene 1 protein, GDF15, MIC1.

 

Description of Human GDF-15 / MIC-1

Recombinant human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 113 amino-acid poly-peptide chains, having a molecular weight of 24.8 kDa. GDF-15 belongs to the TGF- cytokine family, whose mem-bers play an important role during prenatal development and postnatal growth, and the remodelling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15s involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic and prostate cancers.

 

Biological Activity

An ED50 of 1-2g/ml was determined by its ability to inhibit DU-145 cells. An ED50 of 0,2-2 ng/ml was measured by its ability to activate SRE-SEAP reporter in HEK293 human embryonic kidney cells transfected with human c-Ret and human GFRAL.

 

Reconstitution

We recommend a quick spin followed by reconstitution in sterile filtered water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8C for up to 1 week. For extended storage, we recommend to fur-ther dilute into a buffer containing a carrier protein (e.g. 0.1% HSA, order number: 2835.955.xyz or 2835.958.xyz, or BSA, order number: 2835.919.xyz) and store in working aliquots at -20C to -80C.

 

Stability

Lyophilized human GDF-15, although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution GDF-15 can be stored at 4C for 2-7 days and for future use below -18C. Please avoid repeated freeze-thaw cycles.

 

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Amino Acid Sequence

MARNGDHCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI

 

Shipping symbol Shipped at room temperature

 

 

 

 

 

 

 

 

To buy Human GDF-15 / MIC-1 please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button Shopping List & Order Form or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human GDF-15 / MIC-1 is an alternative for the no longer available Promokine GDF-15 (MIC-1), human, recombinant (C-67329).

 

All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.

 

 

 

Payment Methods

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Shipping

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Free shipping for orders above 500 € within Germany

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