Human GDF-15 / MIC-1 (glycosylated, HEK) recombinant Protein

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Phone: +49 (0) 40 . 43 20 84 48 0

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Product Overview, Sizes and Prices

 

Protein

Synonyms: GDF-15, MIC1, MIC-1

Source: HEK

Purity: ≥ 98 % (SDS-PAGE, HPLC)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1437.955.020 20 g 225 €
1437.955.199 1 mg 5.990 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

GDF-15, MIC1, MIC-1

 

Description of Human GDF-15 / MIC-1 (glycosylated, HEK)

Human GDF-15 / MIC-1 (glycosylated; HEK) belongs to the TGF- cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15/MIC-1 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15/MIC-1 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15/MIC-1 in gestation and embryonic development. GDF-15/MIC-1 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of MIC-1/ GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 114 amino-acid polypeptide chains.

 

Stability

The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20C. Reconstituted GDF-15/MIC-1 should be stored in working aliquots at -20C. Please avoid repeated freeze-thaw cycles.

 

 

 

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Payment Methods

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Shipping

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Free shipping for orders above 500  within Germany

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