Human GM-CSF (glycosylated, His-Tag) recombinant Protein

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Product Overview, Sizes and Prices



Synonyms: CSF2, GMCSF.

Source: Insect cells

Purity: ≥ 98 % (SDS-PAGE, silver stained)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1450.952.005 5 µg 185 €
1450.952.020 20 µg 490 €
1450.952.050 50 µg 690 €

Please inquire for other vial sizes and custom vialing.



Product Details




Description of Human GM-CSF (glycosylated, His-Tag)

Recombinant human Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), a 14.5 kDa protein consisting of 127 amino acid residues (Ala18-Glu144), is a potent species specific stimulator of bone marrow cells and several other cell types. GM-CSF was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine or immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages and eosinophils. GM-CSF has also been reported to have a functional role on non-hematopoietic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines. GM-CSF is species specific and human GM-CSF has no biological effects on mouse cells. GM-CSF exerts its biological effects through binding to specific cell surface receptors. The high affinity receptors required for human GM-CSF signal transduction have been shown to be heterodimers consisting of a GM-CSF-specific a chain and a common ß chain that is shared by the high-affinity receptors for IL-3 and IL-5.


Biological Activity

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells [Kitamura T et al, J Cell Physiol, 1989]. The ED50 for this effect is typically <0.1 ng/ml corresponding to a specific activity of ≥1 x 107 units/mg.



The lyophilized rh GM-CSF is soluble in water and most aqueous buffers and can be reconstituted in water to a concentration of 0.1 mg/ml. This solution can be diluted into other buffered solutions or stored at -20 °C for future use.


Lupe Zoom

Amino Acid Sequence



Shipping symbol Shipped at room temperature









To buy Human GM-CSF (glycosylated, His-Tag) (W1450952005, W1450952020, W1450952050) please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human GM-CSF (glycosylated, His-Tag) is an alternative for the no longer available Promokine GM-CSF, human, recombinant (Sf9) (C-60426).


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Errors, changes and availability excepted.




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