Human Growth Hormone Binding Protein recombinant Protein

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Description of Human Growth Hormone Binding Protein

Recombinant Human Growth Hormone Binding Protein produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 248 amino acids and having a molecular mass of 28107.01 Da. The growth hormone receptor (GHR) is a transmembrane protein belonging to the cytokine receptor family. Growth hormone (GH) binds through two distinct receptor-binding sites and induces conformational changes in a preformed receptor dimer, activating signaling pathways involved in growth and development. Mutations that impair binding at the second site can generate GH receptor antagonists. The GHR gene has several variants, including the common exon 3-deleted variant, GHRd3, while pathogenic mutations can cause Laron syndrome, a form of growth hormone insensitivity characterized by severe short stature. Alternative splicing can produce truncated receptor isoforms with reduced intracellular domains. These differ from GHBP, the soluble growth hormone-binding protein, which in humans is generated primarily by proteolytic cleavage of the receptor's extracellular domain.

Biological Activity

GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with G.H.

Reconstitution

It is recommended to reconstitute the lyophilized GHBP in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized GHBP although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GHBP should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA, order number: 2835.955.xyz or 2835.958.xyz, or BSA, order number: 2835.919.xyz). Please avoid repeated freeze-thaw cycles.

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Amino Acid Sequence

AFSGSEATAA ILSRAPWSLQ SVNPGLKTNS SKEPKFTKCR SPERETFSCH WTDEVHHGTK NLGPIQLFYT RRNTQEWTQE WKECPDYVSA GENSCYFNSS FTSIWIPYCI KLTSNGGTVD EKCFSVDEIV QPDPPIALNW TLLNVSLTGI HADIQVRWEA PRNADIQKGW MVLEYELQYK EVNETKWKMM DPILTTSVPV YSLKVDKEYE VRVRSKQRNS GNYGEFSEVL YVTLPQMSQF TCEEDFYF

Shipped at room temperature

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Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

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