Human Haptoglobin, Phenotype 1-1, Low Endotoxin Level

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	Proteins Synonyms: Zonulin, HPT, HP, BP, HP2ALPHA2, HPA1S Source: Human Plasma Purity: ≥ 95% by SDS-PAGE, no visible alpha-2 light chain by SDS-PAGE Endotoxin Level: < 1.0 EU/mg Physical State: Salt-free lyophilized solid. Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-080116-1/1-LEL-1MG 1 mg 290 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

Zonulin, HPT, HP, BP, HP2ALPHA2, HPA1S

 

Description of Human Haptoglobin, Phenotype 1-1, Low Endotoxin Level

Human Haptoglobin, Phenotype 1-1, Low Endotoxin Level is a 86 kDa protein. Human haptoglobin 1-1 (Hp1-1), the most efficient phenotype of the hemoglobin-binding glycoprotein, forms dimers through α1β-chain associations, enabling rapid neutralization of toxic free hemoglobin (Hb) with a binding capacity of 1.25–1.5 mg Hb per mg Hp. Its superior antioxidant capacity stems from compact polymer structures that enhance CD163 receptor-mediated clearance of Hb-Hp complexes by macrophages, suppressing iron-driven oxidative stress and NF-κB inflammatory pathways more effectively than Hp2-1 or Hp2-2 phenotypes. Clinically, Hp1-1 demonstrates protective effects against diabetic vascular complications by preserving endothelial nitric oxide bioavailability and reducing advanced glycation end-product formation, lowering retinopathy and nephropathy risks by 50–70% compared to other phenotypes. In sickle cell disease, Hp1-1 carriers exhibit 40% lower cell-free Hb levels during crises and a twofold reduction in multiorgan failure risk due to enhanced Hb sequestration. Paradoxically, Hp1-1 prevalence increases in cirrhosis (55% vs. 30% in healthy populations) as hepatic synthesis shifts toward acute-phase production despite systemic oxidative stress.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Haptoglobin, Phenotype 1-1, Low Endotoxin Level at -20°C.

 

Applications

Animal Studies, Cell Based Assays, ELISA, Protein Chemistry, Inflammation, Sickle Cell Anemia, Glycosylation, Stroke, Central Nervous System Injury, Diabetes, Cardiovascular Disease, In Vitro Diagnostic, Iron Metabolism, Cancer.

 

Citations/Publications

Chen-Roetling, J., et al., (2016), 'Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin', J. Neurochem., 139: pp. 586--595 Available at: https://doi.org/10.1111/jnc.13720
NCBI: https://www.ncbi.nlm.nih.gov/protein/P00738

 

Shipped with ice packs

 

Gel Scan of Human Haptoglobin, Phenotype 1-1, Low Endotoxin Level

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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