Human IFN-gamma recombinant Protein

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Phone: +49 (0) 40 . 43 20 84 48 0

E-Mail: info@active-bioscience.de

 

Product Overview, Sizes and Prices

 

Protein

Synonyms: Immune IFN, type II IFN, T cell IFN, MAF

Source: E. coli

Biological activity: ≥ 2 x 107 IU/mg.

Purity: ≥ 98 % (SDS-PAGE, RP-HPLC)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1476.950.020 20 g 60 €
1476.950.100 100 g 159 €
1476.950.199 1 mg 890 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

Immune IFN, type II IFN, T cell IFN, MAF

 

Description of Human IFN-gamma

Recombinant human Interferon-gamma (IFN-gamma) is a 17,0 kDa protein containing 144 amino acid residues. IFN-gamma is acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells, which respond to IFN-gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-gamma signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-gamma stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-gamma is species-specific and is biologically active only in human and primate cells.

 

Biological Activity

The ED50 of ≤ 0.05ng/ml was determined in a viral resistance assay. It corresponds to a specific activity of ≥ 2.0 x 107 units/mg.

 

Reconstitution

We recommend a quick spin followed by reconstitution in water or 20mM Acetic acid (AcOH) to a concentration of at least 100 g/ml, which can then be further diluted into other aqueous solutions. Do not vortex. This solution can be stored at 2-8C for up to 1 week or in working aliquots at -20C to -80C. Working aliquots should be at the highest practical concentration. For long term storage we recommend to add at least 0.1% HSA (order number: 2835.955.xyz or 2835.958.xyz) or BSA.

 

Stability

The lyophilized protein is stable at room temperature for up to 1 month and at least until the lot specific expiry date if kept below -18C. Reconstituted IFN-gamma should be stored in working aliquots at -20C to -80C if possible with carrier protein. Please avoid repeated freeze-thaw cycles.

 

Amino Acid Sequence

MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

 

To buy Human IFN-gamma (W1476950020, W1476950100, W1476950199) please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button Shopping List & Order Form to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

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Errors, changes and availability excepted.

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500  within Germany

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