Human IFN-gamma recombinant Protein
Immune IFN, type II IFN, T cell IFN, MAF.
Description of Human IFN-gamma
Recombinant human Interferon-gamma (IFN-gamma) is a 17,0 kDa protein containing 144 amino acid residues. IFN-gamma is acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells, which respond to IFN-gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-gamma signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-gamma stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-gamma is species-specific and is biologically active only in human and primate cells.
The ED50 of ≤ 0.05ng/ml was determined in a viral resistance assay. It corresponds to a specific activity of ≥ 2.0 x 107 units/mg.
We recommend a quick spin followed by reconstitution in water or 20mM Acetic acid (AcOH) to a concentration of at least 100 µg/ml, which can then be further diluted into other aqueous solutions. Do not vortex. This solution can be stored at 2-8°C for up to 1 week or in working aliquots at -20°C to -80°C. Working aliquots should be at the highest practical concentration. For long term storage we recommend to add at least 0.1% HSA (order number: 2835.955.xyz or 2835.958.xyz) or BSA (order number: 2835.919.xyz).
The lyophilized protein is stable at room temperature for up to 1 month and at least until the lot specific expiry date if kept below -18°C. Reconstituted IFN-gamma should be stored in working aliquots at -20°C to -80°C if possible with carrier protein. Please avoid repeated freeze-thaw cycles.
Amino Acid Sequence
MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ
Shipped at room temperature
To buy Human IFN-gamma (W1476950020, W1476950100, W1476950199) please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human IFN-gamma is an alternative for the no longer available Promokine IFN-gamma, human, recombinant (E. coli) (C-60724).
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