Human IFN-lambda-1 / IL-29 recombinant Protein

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Product Overview, Sizes and Prices



Synonyms: Interleukin-29, IL-29, IFN-Lambda 1, IFN-Lambda 1, Cytokine ZCYTO21, IL29, IFNL1, ZCYTO21.

Source: E. coli

Biological activity: See below

Purity: ≥ 90 % (SDS-PAGE, RP-HPLC)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1478.950.005 5 µg 90 €
1478.950.020 20 µg 175 €
1478.950.199 1 mg 2.390 €

Please inquire for other vial sizes and custom vialing.



Product Details


Interleukin-29, IL-29, IFN-Lambda 1, IFN-Lambda 1, Cytokine ZCYTO21, IL29, IFNL1, ZCYTO21.


Description of Human IFN-lambda-1 / IL-29

Recombinant Human IFN-lambda-1/IL-29 derived from E. coli is a 20 kDa single, non-glycosylated, protein consist-ing of 181 amino acids. It is distantly related to type I Interferons (IFNs) and the IL-10 family. Expression of Human IFN-lambda-1 (Interleukin 29) is induced by viral infection which interacts with a heterodimeric class II cytokine re-ceptor that consists of interleukin 10 receptor-beta (IL10rb) and interleukin 28 receptor-alpha. Human IFN-lambda-1 (Interleukin 29) exhibits common features with type I IFNs such as antiviral activity, antiproliferative activity and in vivo antitumor activity. Even so it acts similarly to IFNs, it is generally less effective and has activity only in a more limited range of cell lines. The genes for IFN-lambda-1, IFN-lambda-2 and IFN-lambda-3 are closely positioned on human chromosome 19. Human IFN-lambda-1 (Interleukin 29) induces ELR(-) CXC-chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. It can generate tolerogenic Dendritic Cells (DCs), an activity that could thwart IFN-beta functions. If Human IFN-lambda-1 (Interleukin 29) is produced in response to viral infection, it activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection. IFN-Lambda 1 antiviral and antiproliferative activity requires IFN-Lambda 2 receptor tyrosine residues.


Biological Activity

An ED50 of 0.2-0.5 ng/ml was found by testing its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells.



We recommend a quick spin followed by reconstitution in sterile water to a concentration of at least 100 µg/ml, which can then be further diluted to other aqueous solutions. Do not vortex.



Lyophilized IFN-Lambda-1 is stable at room temperature for up to 3 weeks, but best stored below -18°C. Reconstitut-ed IFN-Lambda-1 can be stored at 4°C for 2-7 days and for future use below -18°C. For long term storage it is rec-ommended to add a carrier protein (0.1% HSA, order number: or, or BSA, order number: Please avoid repeated freeze-thaw cycles.


Lupe Zoom

Amino Acid Sequence



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To buy Human IFN-lambda-1 / IL-29 please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human IFN-lambda-1 / IL-29 is an alternative for the no longer available Promokine IFN-lambda-1 (IL-29), human, recombinant (E. coli) (C-60730).


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Errors, changes and availability excepted.




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