Human IL-1 Receptor Antagonist recombinant Protein

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+49 (0) 40 . 43 20 84 48 0

 

Product Overview, Sizes and Prices

 

Protein

Synonyms: IRAP, IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, MGC10430.

Source: E. coli

Biological activity: ≥ 2 x 106 units/mg

Purity: ≥ 98 % (SDS-PAGE, RP-HPLC)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1501.950.020 20 µg 60 €
1501.950.100 100 µg 159 €
1501.950.199 1 mg 920 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

IRAP, IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, MGC10430.

 

Description of Human IL-1 Receptor Antagonist

Recombinant Human Interleukin-1 Receptor Antagonist (hIL-1RA) is a 17 kDa non-glycosylated, N-terminal methionyl form of the human naturally occurring protein containing 153 amino acids. It is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

 

Biological Activity

The ED50 of ≤ 0.5 ng/ml was determined by the dose-dependant inhibition of IL-1 stimulation of D10S cells. It corresponds to a specific activity of ≥ 2 x 106 units/mg.

 

Reconstitution

We recommend a quick spin followed by reconstitution in sterile water to a concentration of at least 100µg/ml. This solution can then be further diluted to other aqueous solutions.

 

Stability

Lyophilized Interleukin-1 receptor antagonist, although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution hIL-1RA can be stored at 4°C for 2-7 days and for future use below -18°C. If possible, we recommend to add a carrier protein (0.1% HSA, order number: 2835.955.xyz or 2835.958.xyz, or BSA, order number: 2835.919.xyz) for long term storage of the reconstituted hIL1-RA. Generally, working aliquots should be at the highest practical concentration. Please avoid repeated freeze-thaw cycles.

 

Lupe Zoom

Amino Acid Sequence

MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE

 

Shipping symbol Shipped at room temperature

 

 

 

 

 

 

 

 

To buy Human IL-1 Receptor Antagonist please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human IL-1 Receptor Antagonist is an alternative for the no longer available Promokine IL-1 RA, human, recombinant (C-61122).

 

All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.

 

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500 € within Germany

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